748810-25-5Relevant academic research and scientific papers
One-Step, Effective, and Cascade Syntheses of Highly Functionalized Cyclopentenes with High Diastereoselectivity
Alishetty, Suman,Shih, Hong-Pin,Han, Chien-Chung
supporting information, p. 2513 - 2516 (2018/05/17)
Tetrabutylammonium fluoride works as an effective organocatalyst for the cycloaddition between phenacylmalononitriles and electron-deficient olefins (having substituent groups of NO2, CHO, and COR), providing a facile synthetic route to versatile multifunctionalized cyclopentenes having an allylic quaternary carbon center bearing both cyano and carboxamide groups with high yields and high diastereoselectivity. Preliminary studies reveal that these functionalized cyclopentenes are convenient precursors for making α-cyano-functionalized cyclopentadienone oximes.
NEW BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Page/Page column 36, (2017/05/12)
Compounds of formula (I); wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description. Medicaments.
Synthesis of New Pyrrolo[2, 3-b]pyridines as a Potent Inhibitor of Tumour Necrosis Factor Alpha
Mohammed, Khalid,Hilmy, Hassan
, p. 15 - 19 (2007/10/03)
The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines tumor necrosis factor α (TNF-α) and 1L-1β. Accordingly, new pyrrolo[2,3]pyridine derivatives 5 a-d were prepared from 2-amino-3-cyanopyrroles 3 a-d via the intermediate
4-Acylamino-6-arylfuro[2,3-d]pyrimidines: Potent and selective glycogen synthase kinase-3 inhibitors
Maeda, Yutaka,Nakano, Masato,Sato, Hideyuki,Miyazaki, Yasushi,Schweiker, Stephanie L.,Smith, Jeffery L.,Truesdale, Anne T.
, p. 3907 - 3911 (2007/10/03)
Modeling studies of a furo[2,3-d]pyrimidine GSK-3 hit compound 1 superimposed onto the X-ray crystal structure of a legacy pyrazolo[3,4-c] pyridazine GSK-3 inhibitor 2 led to the identification of 4-acylamino-6- arylfuro[2,3-d]pyrimidine template 3. Synth
