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748812-27-3

2-Propenoic acid, 3-phenyl-, 1-naphthalenyl ester, (2E)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 748812-27-3 Structure

  • Basic information

    1. Product Name: 2-Propenoic acid, 3-phenyl-, 1-naphthalenyl ester, (2E)-
    2. Synonyms:
    3. CAS NO:748812-27-3
    4. Molecular Formula: C19H14O2
    5. Molecular Weight: 274.319
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 748812-27-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Propenoic acid, 3-phenyl-, 1-naphthalenyl ester, (2E)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Propenoic acid, 3-phenyl-, 1-naphthalenyl ester, (2E)-(748812-27-3)
    11. EPA Substance Registry System: 2-Propenoic acid, 3-phenyl-, 1-naphthalenyl ester, (2E)-(748812-27-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 748812-27-3(Hazardous Substances Data)

748812-27-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 748812-27-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,8,8,1 and 2 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 748812-27:
(8*7)+(7*4)+(6*8)+(5*8)+(4*1)+(3*2)+(2*2)+(1*7)=193
193 % 10 = 3
So 748812-27-3 is a valid CAS Registry Number.

748812-27-3Relevant articles and documents

Multifunctional cinnamic acid derivatives

Peperidou, Aikaterini,Pontiki, Eleni,Hadjipavlou-Litina, Dimitra,Voulgari, Efstathia,Avgoustakis, Konstantinos

, (2017)

Our research to discover potential new multitarget agents led to the synthesis of 10 novel derivatives of cinnamic acids and propranolol, atenolol, 1-adamantanol, naphth-1-ol, and (benzylamino) ethan-1-ol. The synthesized molecules were evaluated as trypsin, lipoxygenase and lipid peroxidation inhibitors and for their cytotoxicity. Compound 2b derived from phenoxyphenyl cinnamic acid and propranolol showed the highest lipoxygenase (LOX) inhibition (IC50 = 6 uM) and antiproteolytic activity (IC50 = 0.425 uM). The conjugate 1a of simple cinnamic acid with propranolol showed the higher antiproteolytic activity (IC50 = 0.315 uM) and good LOX inhibitory activity (IC50 = 66 uM). Compounds 3a and 3b, derived from methoxylated caffeic acid present a promising combination of in vitro inhibitory and antioxidative activities. The S isomer of 2b also presented an interesting multitarget biological profile in vitro. Molecular docking studies point to the fact that the theoretical results for LOX-inhibitor binding are identical to those from preliminary in vitro study.

Flavonoids and cinnamic acid esters as inhibitors of fungal 17β-hydroxysteroid dehydrogenase: A synthesis, QSAR and modelling study

Sova, Matej,Perdih, Andrej,Kotnik, Miha,Kristan, Katja,Rizner, Tea Lanisnik,Solmajer, Tom,Gobec, Stanislav

, p. 7404 - 7418 (2008/02/01)

The 17β-hydroxysteroid dehydrogenases (17β-HSDs) modulate the biological potency of estrogens and androgens by interconversion of inactive 17-keto-steroids and their active 17β-hydroxy- counterparts. We have shown previously that flavonoids are potentially useful lead compounds for developing inhibitors of 17β-HSDs. In this paper, we describe the synthesis and biochemical evaluation of structurally analogous inhibitors, the trans-cinnamic acid esters and related compounds. Additionally, quantitative structure-activity relationship (QSAR) and modelling studies were performed to rationalize the results and to suggest further optimization. The results stress the importance of a hydrogen bond with Asn154 and hydrophobic interactions with the aromatic side chain of Tyr212 for optimal molecular recognition.

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