74882-52-3

Upstream product

• 67-56-1 methanol 
• 150483-54-8 N-benzyl-2-nitrosobenzamide 
• 56070-95-2 3-benzylideneamino-1,2,3-benzotriazin-4-one 
• 4036-59-3 2-benzylidene-1-(2-carboxyphenyl)hydrazine 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 52745-10-5 N-(phenylmethyl)-2-nitrobenzamide 

Downstream Products

• 686268-74-6 methyl 2-[2-benzylidene-1-(3-ethoxy-3-oxopropanoyl)hydrazino]benzoate 
• 686268-75-7 ethyl 4-hydroxy-2-oxo-1-{[phenylmethylene]amino}-1,2-dihydroquinoline-3-carboxylate 

Relevant academic research and scientific papers

HCV INHIBITORS

The present invention provides HCV polymerase inhibiting compounds having the formula (I) where R1is cyclobutyl-N(Ra)-, n is 1, 2, 3 or 4, and at least one R5 is RaSO2N(Rj)alkyl-. In a non-

Anti-infective agents

Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

Electrosynthesis and in situ chemical rearrangement of o-nitrosobenzamides

Primary and secondary o-nitrosobenzamides can be prepared in a "redox" cell but are unstable in the solvent used for electrolysis (acetate buffer-alcohol).At room temperature N-aryl-2-nitrosobenzamides give 2-carboxyazobenzenes.N-alkyl-2-nitrosobenzamides decompose thermally into 2-methoxy or 2-ethoxycarbonylphenylhydrazones according to the alcohol used.Similarly, methyl benzoate (or ethyl benzoate) is obtained from 2-nitrosobenzamide.A possible mechanism involves an unstable heterocycle formed by the coupling of the two nitrogen atoms (nitroso and amide) followed by cleavage of the carbonyl-nitrogen bond resulting from nucleophilic attack of the solvent (water or alcohol). Key Words: flow cell electrosynthesis / 2-nitrosobenzamides / 2-carboxyazobenzenes / 2-alkoxycarbonylphenylhydrazones / indazol-3-one

1,2,3-Benzotriazin-4-ones and Related Systems. Part 6. Thermal and Photolytic Decomposition of 3-Arylideneamino-, 3-Imidoyl-, and 3-Heteroaryl-1,2,3-benzotriazin-4-ones

Thermal decomposition of 3-arylideneamino- and 3-imidoyl-1,2,3-benzotriazin-4-ones in solution gives 2-arylquinazolin-4-ones and 1,2-diaryl-1,4-dihydroquinazolin-4-ones, respectively.In the latter decompositions phenanthridones are also formed in minor but substantial (20percent) yield.Possible mechanisms to account for these products are discussed.Photolysis of the 3-arylideneamino-derivatives in methanol provides a useful synthesis of aldehyde o-(methoxycarbonyl)phenylhydrazones. 3-(α-Pyridyl)- and 3-thiazol-2-yl-1,2,3-benzotriazin-4-one undergo thermal decomposition to pyridoquinazolin-11-one and thiazoloquinazolin-5-one, respectively.