74897-27-1Relevant articles and documents
Tricyclic Systems Obtained from Some 3-Aminobenzothiophen Derivatives
Clarke, Kenneth,Fox, William Richard,Scrowston, Richard M.
, p. 833 - 847 (2007/10/02)
4-Hydroxybenzothienopyridin-2(1H)-one (3) was obtained by cyclisation of a benzothiophen derivative containing either 2-CO2Et, 3-NH.CO.CH2.CO2Et or 2-CO.CH2.CO2Et, 3-NH2 substituents. 3-Amino-2-formyl-, 3-amino-2-acetyl-, and 3-amino-2-acetyl-5-nitro-benzothiophens were converted into the corresponding 3-thiocyanato-compounds, which gave tricyclic systems when treated with hydroxylamine.Heating these with polyphosphoric acid gave benzothienoisothiazole, and its 3-methyl and 3-methyl-7-nitro-derivatives respectively.Nitration, formylation, and oxidation reactions of 3-methylbenzothienoisothiazole have been investigated.