749-13-3 Usage
Uses
Used in Psychiatry:
Trifluperidol is used as an antipsychotic agent for the treatment of psychoses accompanied by motor and mental excitement. It is particularly effective in managing prolonged attacks of recurrent schizophrenia, cases accompanied by severe depression and delirium, and alcoholic psychoses. Its ability to stop minor manic excitement surpasses that of other neuroleptics, making it a valuable asset in psychiatric care.
Used in Anesthesia:
In the field of anesthesia, trifluperidol is used as an adjunct to enhance the action of soporifics, narcotics, and analgesics. This helps in achieving a more effective and controlled sedation, analgesia, and anesthesia during surgical procedures.
Used in Emergency Medicine:
Trifluperidol is used as an anticonvulsant and antiemetic agent in emergency medicine, particularly in cases of severe agitation, seizures, and vomiting. Its rapid onset of action and effectiveness in controlling these symptoms make it a valuable tool in emergency situations.
Used in Palliative Care:
In palliative care, trifluperidol is used as a potent antipsychotic drug to manage symptoms such as agitation, delirium, and hallucinations in patients with advanced illnesses. Its ability to enhance the action of sedatives and analgesics also contributes to improved comfort and quality of life for these patients.
Safety Profile
Poison by ingestion,
subcutaneous, and intraperitoneal routes. An
experimental teratogen. Experimental
reproductive effects. When heated to
decomposition it emits very toxic fumes of
Fand NOx. See also FLUORIDES and
TRIFLUPERIDOL HYDROCHLORIDE.
Synthesis
Trifluperidol, 4-[4-(α,α,α-trifluoro-m-tolyl)-4-hydroxypiperidino]-4′- fluorobutirophenone (6.3.3), is synthesized by reacting 1-benzyl-4-piperidone (3.1.48) with a Grignard reagent prepared from 1-trifluoromethyl-3-bromobenzene and magnesium that forms 1-benzyl-4-hydroxy-4-(3-trifluoromethylphenyl)piperidine (6.3.1), the reduction of which with hydrogen in the presence of a palladium on carbon catalyst removes the benzyl protecting group giving 4-hydroxy-4-(3-trifluoromethylphenyl)piperidine (6.3.2). Alkylation of the nitrogen atom of the last by ω–chloro-4-fluorobutyrophenone gives trifluperidol (6.3.3).
The 4'-chloro-4-fluorobutirophenone (6.3.4) needed for this is synthesized by the acylation of fluorobenzene using 4-chlorobutyric acid chloride.
Check Digit Verification of cas no
The CAS Registry Mumber 749-13-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,4 and 9 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 749-13:
(5*7)+(4*4)+(3*9)+(2*1)+(1*3)=83
83 % 10 = 3
So 749-13-3 is a valid CAS Registry Number.
InChI:InChI=1/C22H23F4NO2/c23-19-9-3-16(4-10-19)20(28)2-1-13-27-14-11-21(29,12-15-27)17-5-7-18(8-6-17)22(24,25)26/h3-10,29H,1-2,11-15H2
749-13-3Relevant academic research and scientific papers
Phenylbutanol derivatives
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, (2008/06/13)
Butyrophenone derivatives having excellent psychotropic activity and represented by the formula, SPC1 Wherein A represents a single or double bond linkage; R1 represents a hydrogen atom or a C1 - C4 alkyl group; R2, which is present only in case A represents a single bond linkage, represents a hydrogen atom, or a hydroxyl, C1 - C4 alkyl, or C1 - C4 alkoxy group; R3 represents a hydrogen atom, or a piperidino, pyrrolidino, morpholino, furyl, thienyl, C1 - C4 alkylamino, benzylamino, unsubstituted or halogen-substituted phenyl group, etc.; and X represents a hydrogen or halogen atom, or a C1 - C4 alkyl, C1 - C4 alkoxy, or trifluoromethyl group, can be prepared by reducing a benzoylpropionamide derivative of the formula, SPC2 Wherein A, R1, R2, R3 and X have the same meanings as defined above, to a phenylbutanol derivative of the formula, SPC3
