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| CAS No.: | 749-13-3 |
|---|---|
| Name: | trifluperidol |
| Molecular Structure: | |
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| Formula: | C22H23 F4 N O2 |
| Molecular Weight: | 409.424 |
| Synonyms: | Butyrophenone,4'-fluoro-4-[4-hydroxy-4-(a,a,a-trifluoro-m-tolyl)piperidino]- (6CI,7CI,8CI);4'-Fluoro-4-[4-hydroxy-4-(a,a,a-trifluoro-m-tolyl)piperidino]butyrophenone;Flumoperone; McN-JR 2498; NSC 170978; P 459; Psicoperidol; R 2498;Trifluoperidol; Trifluperidol; Trifluperol; Triperidol; Trisedil; p-Fluoro-g-[4-hydroxy-4-(3-trifluoromethylphenyl)piperidino]butyrophenone |
| Density: | 1.26g/cm3 |
| Boiling Point: | 535.7°C at 760 mmHg |
| Flash Point: | 277.8°C |
| Safety: | Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F− and NOx. See also FLUORIDES and TRIFLUPERIDOL HYDROCHLORIDE. |
| PSA: | 40.54000 |
| LogP: | 4.72890 |
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Chemistry
IUPAC Name: 1-(4-Fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidyl]butan-1-one
Synonyms of Trifluperidol (CAS NO.749-13-3) : 1-Butanone, 1-(4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)-1-piperidinyl)- ; 4'-Fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino butyrophenone ; Flumoperone ; Psicoperidol ; Trifluperidol ; Trisedil ; Butyrophenone, 4'-fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino)-
InChI:InChI=1/C22H23F4NO2/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26/h1,3-4,6-9,15,29H,2,5,10-14H2
CAS NO:749-13-3
Molecular Formula:C22H23F4NO2
Molecular Weight :409.4171
Molecular Structure :
Index of Refraction: 1.534
Surface Tension: 41.1 dyne/cm
Density: 1.26 g/cm3
Flash Point: 265.8 °C
Enthalpy of Vaporization: 82.95 kJ/mol
Boiling Point: 515.9 °C at 760 mmHg
Vapour Pressure: 1.8E-11 mmHg at 25°C
Uses
Trifluperidol (CAS NO.749-13-3) is a typical antipsychotic of the butyrophenone chemical class.It is used in the treatment of psychoses including mania and schizophrenia.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | subcutaneous | > 2500ug/kg (2.5mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961. | |
| dog | LD50 | subcutaneous | > 80mg/kg (80mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961. | |
| monkey | LD50 | subcutaneous | > 1250ug/kg (1.25mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961. | |
| mouse | LD50 | intravenous | 26mg/kg (26mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961. | |
| mouse | LD50 | oral | 110mg/kg (110mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1248, 1974. |
| mouse | LD50 | subcutaneous | 50mg/kg (50mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1248, 1974. |
| mouse | LDLo | intraperitoneal | 150mg/kg (150mg/kg) | National Technical Information Service. Vol. AD691-490, | |
| rat | LD50 | intravenous | 14mg/kg (14mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961. | |
| rat | LD50 | oral | 140mg/kg (140mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
| rat | LD50 | subcutaneous | 70mg/kg (70mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE AUTONOMIC NERVOUS SYSTEM: CENTRAL SYMPATHOLYTIC BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING | Medicinal Chemistry: A Series of Monographs. Vol. 4(2), Pg. 199, 1967. |
Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F− and NOx. See also FLUORIDES and TRIFLUPERIDOL HYDROCHLORIDE.
Specification
Trifluperidol (CAS NO.749-13-3) has general properties similar to those of haloperidol, but is considerably more potent by weight, and causes relatively more severe side effects, especially tardive dyskinesia and other extrapyramidal effects.