74912-78-0Relevant articles and documents
A New Synthetic Approach towards Adriamycin
Barton, Derek H. R.,Dawes, Clive C.,Franceschi, Giovanni,Foglio, Maurizio,Ley, Steven V.,et al.
, p. 643 - 647 (2007/10/02)
An improved route to 3,4-dihydro-2-phenylnaphthofuran-5-one (2) and a convenient preparation of furan-3,4-dicarbaldehyde (4) are described.The dihydro-derivative of (2) was condensed with (4) to give 4-(4-formyl-3-furylmethyl)-2-phenylnaphthofuran-5-one (5), which after preparation of its 1,3-dithiolan derivative was photocyclized to a polycyclic compound (7).Owing to problems of deprotection of (7) further steps towards adriamycin (1) were abandoned.