74912-80-4

Upstream product

• 611-74-5 N,N-dimethylbenzamide 
• 20214-43-1 ethane-1,1,2,2-tetracarbaldehyde dipotassium salt 
• 74894-03-4 4-<(4-formyl-3-furyl)methyl>-2-phenylnaphtho<1,8-b,c>furan-5-one 
• 74912-78-0 2,3-bis-(dimethylamino-methylene)-succinaldehyde 
• 569-42-6 1,8-dihydroxynaphthalene 
• 32848-65-0 3,4-dihydro-2-phenylnaphtho<1,8-b,c>furan-5-one 
• 32848-64-9 2-phenyl-naphtho[1,8-bc]furan-5-one 
• 7040-25-7 3,4-diformylfuran 

Relevant academic research and scientific papers

A New Synthetic Approach towards Adriamycin

An improved route to 3,4-dihydro-2-phenylnaphthofuran-5-one (2) and a convenient preparation of furan-3,4-dicarbaldehyde (4) are described.The dihydro-derivative of (2) was condensed with (4) to give 4-(4-formyl-3-furylmethyl)-2-phenylnaphthofuran-5-one (5), which after preparation of its 1,3-dithiolan derivative was photocyclized to a polycyclic compound (7).Owing to problems of deprotection of (7) further steps towards adriamycin (1) were abandoned.