749167-08-6Relevant academic research and scientific papers
Diastereoselective synthesis of a core fragment of ritonavir and lopinavir
Roy, Arnab,Reddy, Lekkala Amarnath,Dwivedi, Namrata,Naram, Jyothirmayi,Swapna, Rodda,Malakondaiah, Golla China,Ravikumar, Mylavarpu,Bhalerao, Dinesh,Pratap, Taduri Bhanu,Reddy, Padi Pratap,Bhattacharya, Apurba,Bandichhor, Rakeshwar
scheme or table, p. 6968 - 6970 (2012/02/13)
A novel approach to the synthesis of Boc-core, a key starting material for ritonavir and lopinavir involving an unprecedented diastereoselective nitroaldol reaction on β-amino aldehyde is disclosed.
EPC-synthesis of functionalised amides via chiral β-nitrogenated organolithium compounds
Foubelo, Francisco,Yus, Miguel
, p. 2911 - 2922 (2007/10/03)
The deprotonation of chiral chloroamides or carbamates 1, 4, 7, 10, 13 and 16 with n-butyllithium followed by in situ lithiation with lithium naphthalenide, both at -78°C in THF, leads to the formation of the corresponding chiral dianionic intermediates,
Synthesis of enantiomerically pure functionalised amides (EPC-synthesis) from chiral β-aminated organolithium intermediates
Foubelo, Francisco,Yus, Miguel
, p. 4831 - 4834 (2007/10/02)
The successive deprotonation-lithiation of chiral chloroamides 1 with n-butyllithium and lithium naphthalenide, respectively, at -78°C leads to the corresponding chiral β-aminated organolithium intermediates 2, which by reaction with different electrophil
