74919-31-6

Basic information

• Product Name: 2-Ethoxy-3-Bromo-5-Nitropyridine
• Synonyms: 2-Ethoxy-3-Bromo-5-Nitropyridine
• CAS NO: 74919-31-6
• Molecular Formula: C7H7BrN2O3
• Molecular Weight: 247.04608
• Product Categories: Pyridine
• Mol File: 74919-31-6.mol

Chemical Properties

• Boiling Point: 298.603 °C at 760 mmHg
• Flash Point: 134.39 °C
• Appearance: /
• Density: 1.634 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 2-Ethoxy-3-Bromo-5-Nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethoxy-3-Bromo-5-Nitropyridine(74919-31-6)
• EPA Substance Registry System: 2-Ethoxy-3-Bromo-5-Nitropyridine(74919-31-6)

Safety Data

• Hazardous Substances Data: 74919-31-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Ethoxy-3-Bromo-5-Nitropyridine is used as an intermediate in the synthesis of various pharmaceutical compounds due to its ability to be easily modified and incorporated into diverse synthetic routes. Its selective reactivity and functional group versatility make it a preferred choice for the development of new drugs.
Used in Agrochemical Production:
In the agrochemical sector, 2-Ethoxy-3-Bromo-5-Nitropyridine is utilized as a key intermediate for the production of agrochemicals, contributing to the development of effective and targeted pest control solutions.
Used in Research and Development:
2-Ethoxy-3-Bromo-5-Nitropyridine is employed as a reagent in organic synthesis within research and development settings, facilitating the exploration of new chemical pathways and the creation of innovative synthetic compounds.
Used in Manufacturing Active Pharmaceutical Ingredients:
As an important starting material, 2-Ethoxy-3-Bromo-5-Nitropyridine plays a crucial role in the manufacturing process of active pharmaceutical ingredients, ensuring the production of high-quality and efficacious medications.

InChI:InChI=1/C7H7BrN2O3/c1-2-13-7-6(8)3-5(4-9-7)10(11)12/h3-4H,2H2,1H3

Upstream product

• 15862-36-9 2,3-dibromo-5-nitropyridine 
• 141-52-6 sodium ethanolate 
• 368-39-8 triethyloxonium fluoroborate 

Relevant articles and documents

NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF

An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. Th e present invention provides a nicotinamide derivative represented by the follo wing formula (I) (wherein R 1 represents a halogen atom; R 2 represents a C 1-12 alkyl group, a C 2-12 alkenyl group, a C 2-12 alkynyl group, a C 3-8 cycloalkyl g roup, an aryl group, an ar-C 1-6 alkyl group or a heterocyclic group, each opti onally having at least one substituent; R 3 represents an aryl group or a hetero cyclic group each optionally having at least one substituent; and R 4 and R 5 e ach independently represent a hydrogen atom; and R 2 and R 4 may form a cyc lic amino group optionally having at least one substituent together with the ni trogen atom to which they bind) or a salt thereof, and a pharmaceutical comp osition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.

The amination of 3-bromo-2-ethoxy-1,5-naphthyridine. A reinvestigation.

The reaction of 3-bromo-2-ethoxy-1,5-naphthyridine with KNH2/NH3 was reinvestigated.The procedure, described in the literature for the preparation of the title compound does not lead to this compound but to the isomeric 3-bromo-1-ethyl-1,5-naphthyridin-2(1H)-one.Reaction of this compound with KNH2/NH3 yields 3- and 4-amino-1-ethyl-1,5-naphthyridin-2(1H)-one, the latter being the main product.The title compound was prepared on reacting 2,3-dibromo-1,5-naphthyridine with sodium ethoxide.A mixture of 3- and 4-amino-2-ethoxy-1,5-naphthyridine was obtained on amination of 3-bromo-2-ethoxy-1,5-naphthyridine.In both cases the intermediacy of the respective 3,4-didehydro compounds was proposed.