74919-57-6

Upstream product

• 2198-19-8 2'-hydroxy-4,4'-dimethoxychalcone 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 20979-50-4 4,7-dimethoxyflavone 
• 224644-50-2 acetic acid 4-methoxy-2-(3-propionyl)phenyl ester 
• 89622-16-2 7,4'-dimethoxy-3-benzylchroman-4-one 
• 224644-51-3 7-methoxy-2-methyl-3-(4'-methoxybenzyl)-4H-1-benzofuran-4-one 
• 105245-58-7 2'-Hydroxy-4,4'-dimethoxy-α-hydroxymethyldihydrochalcone 

Relevant academic research and scientific papers

Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents

Twenty-one chalcones were prepared via aldol condensation and subsequent reduction of these compound led to the corresponding dihydrochalcone and 1,3-diphenylpropane derivatives. The synthetic products were examined for their effects on NO inhibition in L

Pd-C/ammonium formate: A selective catalyst for the hydrogenation of chalcones to dihydrochalcones

Pd-C/ammonium formate is a highly efficient catalyst for the selective hydrogenation of chalcones to dihydrochalcones (DHCs). The reaction proceeds under mild conditions and the Pd-C catalyst is recovered without loss of activity.

Synthesis and activity of a new series of chalcones as aldose reductase inhibitors

A new series of chalcone derivatives has been synthesized and tested in vitro in order to assess their ability to inhibit aldose reductase enzyme (ALR2) and their specificity towards the target enzyme with respect to other oxidoreductases, such as aldehyde reductase, sorbitol dehydrogenase, and glutathione reductase. All the compounds display affinity for ALR2. The X-ray crystal structure of 1-(2,4-dihydroxyphenyl)-3-(2-methoxyphenyl)propen-1-one was determined.

A simple and efficient conversion of chalcones to dihydrochalcones

The remarcable efficiency of catalytic transfer hydrogenation of chalcones to dihydrochalcones using cyclohexene-Pd/C and ammonium formate-Pd/C is demonstrated.The method is preparatively simple and useful.

Selective Reduction in 2'-Hydroxychalcones

The selective reduction of double bond in 2'-hydroxychalcones with sodium dithionite under phase transfer catalysed conditions is described.