749262-40-6Relevant academic research and scientific papers
α,α-Difluoro-β-ketophosphonates as potent inhibitors of protein tyrosine phosphatase 1B
Li, Xianfeng,Bhandari, Ashok,Holmes, Christopher P.,Szardenings, Anna K.
, p. 4301 - 4306 (2007/10/03)
A novel series of inhibitors that contain an aryl α,α-difluoro- β-ketophosphonate group has been synthesized and evaluated against protein tyrosine phosphatase 1B. These compounds exhibit strong inhibitory activity, the best of which has a Ki value of 0.17μM. These results demonstrate that aryl α,α-difluoro-β-ketophosphonates are powerful phosphotyrosine mimetics for the development of potent PTP inhibitors.
