74927-23-4Relevant academic research and scientific papers
CHELATION-CONTROLLED NUCLEOPHILIC ADDITIONS. 2. A HIGHLY EFFECTIVE SYSTEM FOR ASYMMETRIC INDUCTION IN THE REACTION ON ORGANOMETALLIC WITH β-ALKOXYALDEHYDES.
Still, W. Clark,Schneider, Josef A.
, p. 1035 - 1038 (1980)
Organocuprates have been found to be highly stereoselective reagents for the addition of carbanionic nucleophiles to α-asymmetric aldehydes bearing β-oxigen substituents.The major products are those predicted by a chelation-controlled transition state and have diastereomeric purities ranging from 15-30:1.
