CHELATION-CONTROLLED NUCLEOPHILIC ADDITIONS. 2. A HIGHLY EFFECTIVE SYSTEM FOR ASYMMETRIC INDUCTION IN THE REACTION ON ORGANOMETALLIC WITH β-ALKOXYALDEHYDES.

Article abstract of DOI:10.1016/S0040-4039(00)78832-0

Organocuprates have been found to be highly stereoselective reagents for the addition of carbanionic nucleophiles to α-asymmetric aldehydes bearing β-oxigen substituents.The major products are those predicted by a chelation-controlled transition state and have diastereomeric purities ranging from <*>15-30:1.