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74936-81-5

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74936-81-5 Usage

Uses

2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic Acid is used in the preparation of benidipine hydrochloride metabolites. Benidipine is a highly potent and long-?acting Calcium antagonist now under study as an antihypertensive and as an antianvginal agent.

Check Digit Verification of cas no

The CAS Registry Mumber 74936-81-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,9,3 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 74936-81:
(7*7)+(6*4)+(5*9)+(4*3)+(3*6)+(2*8)+(1*1)=165
165 % 10 = 5
So 74936-81-5 is a valid CAS Registry Number.

74936-81-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-pyridine-3,5-dicarboxylic acid

1.2 Other means of identification

Product number -
Other names 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:74936-81-5 SDS

74936-81-5Upstream product

74936-81-5Relevant articles and documents

Synthesis of expected metabolites of benidipine hydrochloride

Muto,Kuroda,Kawato,Nishikawa,Nakamizo

, p. 1666 - 1670 (2007/10/02)

(±)-(R*)-2,6-Dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5- dicarboxylic acid (R*)-1-benzyl-3-piperidinyl ester, methyl ester hydrochloride (benidipine hydrochloride, KW-3049, 1) a highly potent and long-acting calcium antagonistic 1,4-dihydropyridine derivative, is now under clinical study as an antihypertensive and as an antianginal agent. In order to confirm the structures of the metabolites of KW-3049, 19 compounds were prepared. Among then 11 compounds were found to be metabolites (the compounds 2, 3, 6, 8, 14, 15, 16, 28, 31, 32 and 34) of KW-3049 in rats and/or dogs.

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