7494-34-0

Usage

Uses

Used in Pharmaceutical Industry:
27-Nor-25-ketocholesterol is used as an intermediate in the synthesis of hydroxy derivatives of cholesterol (C432501) for the development of pharmaceutical products. These hydroxy derivatives have potential applications in treating various medical conditions due to their influence on cellular processes and signaling pathways.

InChI:InChI=1/C26H42O2/c1-17(6-5-7-18(2)27)22-10-11-23-21-9-8-19-16-20(28)12-14-25(19,3)24(21)13-15-26(22,23)4/h8,17,20-24,28H,5-7,9-16H2,1-4H3/t17-,20+,21+,22-,23+,24+,25+,26-/m1/s1

Upstream product

• 83872-49-5 25,25-Aethylendioxy-6β-methoxy-27-nor-3β,5-cyclo-5α-cholestan 
• 83872-50-8 (23E)-3β-Hydroxy-27-nor-5,23-cholestadien-25-on 
• 75303-37-6 2-[(3S,8S,9S,10R,13R,14S,17R)-17-((R)-4-Bromo-1-methyl-butyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-tetrahydro-pyran 
• 83872-45-1 (20S)-(20-Methyl-5-pregnen-3β,21-diol)-21-p-toluolsulfonat 
• 51231-24-4 (20S)-(6β-Methoxy-20-methyl-3α,5-cyclo-5α-pregnan-21-ol)-p-toluolsulfonat 
• 58507-66-7 (20S)-(20-Methyl-3β-<(tetrahydropyran-2-yl)oxy>-5-pregnen-21-ol)-p-toluolsulfonat 
• 213828-18-3 2-[(R)-2-Benzenesulfonyl-4-((1aR,3aR,3bS,5aR,6R,8aS,8bS,10R,10aR)-10-ethoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-pentyl]-2-methyl-[1,3]dioxolane 
• 514-50-1 3β-acetoxy-5α,6β-dibromocholestane 

Downstream Products

• 32557-11-2 (R)-6-((3S,8S,9S,10R,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-heptanal 
• 13095-61-9 26-hydroxycholesterol 
• 13095-61-9 (25R)-cholest-5-ene-3β,26-diol 
• 2140-46-7 25-hydroxychlolesterol 

Relevant academic research and scientific papers

Lipase-catalyzed resolution of stereogenic centers in steroid side chains by transesterification in organic solvents: The case of a 26- hydroxycholesterol

The Pseudomonas cepacia (PCL) lipase selectively catalyzes the acylation of the (25S)-isomer of the (25R,S)-26-hydroxycholesterol 1a when the transesterification is irreversibly carried out with vinyl acetate in a mixture of organic solvents (chloroform/t

SYNTHETIC STUDIES ON VITAMIN D ANALOGUES VI. A NEW SYNTHESIS OF 25-HYDROXYCHOLESTEROL FROM LITHOCHOLIC ACID

The conversion of lithocholic acid (1) into 25-hydroxycholesterol (10) via methyl 3β-hydroxy-5-cholenate (6) is described.

Preparation of 3β-hydroxy-27-norcholest-5-ene-25-one and intermediates thereof

A process for preparing 3β-hydroxy-27-norcholest-5-ene-25-one, a useful intermediate in the synthesis of 25-acetoxy vitamin D3, novel intermediates, and preparation thereof are disclosed.