74949-52-3Relevant articles and documents
FACILE SYNTHESIS OF 2-AZETIDINONES WITH AN OLEFINIC SUBSTITUENT AT THE C-4 POSITION
Shibuya, Masayuki,Kubota, Seiju
, p. 601 - 609 (2007/10/02)
A novel, facile synthesis of 2-azetidinones having an olefinic side chain at the C-4 position is described.Isoxazolones (7) derived from β-keto esters (6) were converted to β-amino esters (8) in excellent yield by reduction with sodium in isopropyl alcohol followed by esterification.Then reaction of the β-amino esters with o-tolylmagnesium bromide in dichloromethane gave the desired 2-azetidinones (2)-(5).