66248-79-1

Upstream product

• 58544-20-0 ethyl 2,2-dimethyl-3-butenoate 
• 141-78-6 ethyl acetate 
• 57690-96-7 2,2-dimethylbut-3-enoyl chloride 
• 1071-46-1 hydrogen ethyl malonate 
• 105-56-6 ethyl 2-cyanoacetate 
• 870-63-3 prenyl bromide 
• 366-18-7 [2,2]bipyridinyl 
• 79-37-8 oxalyl dichloride 
• 10276-09-2 2,2-dimethyl-but-3-enoic acid 
• 7505-94-4 ethyl 3-hydroxy-2,2-dimethylbutanoate 
• 316148-56-8 ethyl 2,2-dimethyl-3-(4-toluenesulfonyloxy)butanoate 
• 714273-85-5 2,2-dimethyl-3-(toluene-4-sulfonyloxy)-butyric acid methyl ester 
• 19757-86-9 methyl 2,2-dimethyl-3-pentenoate 
• 69737-23-1 methyl 3-hydroxy-2,2-dimethylbutanoate 

Downstream Products

• 546-49-6 artemisia ketone 
• 55233-98-2 ethyl 2-oxo-3,3-dimethyl-cyclohexanecarboxylate 
• 819796-37-7 ethyl 6-hydroxy-3,3-dimethyl-2-oxo-cyclohexanecarboxylate 
• 794587-06-7 {(1R,3S,5R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-8,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]non-6-en-1-yl}-acetic acid ethyl ester 
• 794587-09-0 {(1R,3S,5R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-8,8-dimethyl-7-oxo-2,9-dioxa-bicyclo[3.3.1]non-1-yl}-acetic acid ethyl ester 
• 794587-11-4 (1R,3S,5R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-8,8-dimethyl-1-((E)-4-oxo-pent-2-enyl)-2,9-dioxa-bicyclo[3.3.1]nonan-7-one 
• 794587-08-9 {(1R,3S,5R,6R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-6-hydroxy-8,8-dimethyl-7-oxo-2,9-dioxa-bicyclo[3.3.1]non-1-yl}-acetic acid ethyl ester 
• 794587-07-8 {(1R,3S,5R,6S,7S)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-6,7-dihydroxy-8,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]non-1-yl}-acetic acid ethyl ester 
• 794587-03-4 (1R,3S,5R)-1-[(E)-4-(tert-Butyl-dimethyl-silanyloxy)-penta-2,4-dienyl]-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-8,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonan-7-one 
• 794587-12-5 (1R,3S,5R)-1-[(2R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,2-diethyl-[1,3]dioxolan-4-yl)-5,6-dihydro-2H-pyran-2-ylmethyl]-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-8,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonan-7-one 
• 794587-19-2 (1R,3S,5S,7S)-1-[(2R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,2-diethyl-[1,3]dioxolan-4-yl)-5,6-dihydro-2H-pyran-2-ylmethyl]-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-8,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]nonan-7-ol 
• 794587-02-3 Acetic acid (1R,3S,5R,7S)-1-[(2R,6R)-4-(tert-butyl-dimethyl-silanyloxy)-6-((S)-2,2-diethyl-[1,3]dioxolan-4-yl)-5,6-dihydro-2H-pyran-2-ylmethyl]-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-8,8-dimethyl-2,9-dioxa-bicyclo[3.3.1]non-7-yl ester 
• 714273-82-2 1-acetyl-3-{(Z)-1-[5-(1,1-dimethyl-2-propenyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione 
• 351325-37-6 3Z-benzylidene-6Z-[[5-(1,1-dimethyl-2-propenyl)-1H-imidazol-4-yl]methylene]-2,5-piperazinedione 

Relevant academic research and scientific papers

ANALOGS OF DEHYDROPHENYLAHISTINS

Analogs of dehydrophenylahistins are disclosed as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

ANALOGS OF DEHYDROPHENYLAHISTINS AND THEIR THEAPEUTIC USE

Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof

Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1′, R1″, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.

Sequential hydroformylation/aldol reactions: Versatile and controllable access to functionalised carbocycles from unsaturated carbonyl compounds

Three different modes of hydroformylation/aldol reaction sequences involving either acid-catalysed aldol reactions, Mukaiyama aldol addition of pre-formed enolsilanes or aldol addition of in situ generated boron enolates can be applied to unsaturated ketones and ketoesters to afford the corresponding carbocyclic aldol adducts in good yields proceeding through the intermediate activated ketoaldehydes. In selected cases, complimentary, synthetically useful diastereoselectivities were observed in the products.

Sequential enolboration/hydroformylation/aldol addition: A new one-pot cascade reaction for the regio- and diastereoselective formation of carbocyclic quaternary centres from acyclic olefins

Starting from unsaturated carbonyl compounds a mild new cascade reaction involving enolboration, rhodium-catalysed hydroformylation and intramolecular aldol addition in a regio- and diastereoselective fashion leads to cyclic compounds containing highly-functionalised quaternary carbon centres.

FACILE SYNTHESIS OF 2-AZETIDINONES WITH AN OLEFINIC SUBSTITUENT AT THE C-4 POSITION

A novel, facile synthesis of 2-azetidinones having an olefinic side chain at the C-4 position is described.Isoxazolones (7) derived from β-keto esters (6) were converted to β-amino esters (8) in excellent yield by reduction with sodium in isopropyl alcohol followed by esterification.Then reaction of the β-amino esters with o-tolylmagnesium bromide in dichloromethane gave the desired 2-azetidinones (2)-(5).