7495-58-1Relevant academic research and scientific papers
Induction of apoptosis promoted by Bang52; a small molecule that downregulates Bcl-xL
Rossi, Matteo,Bang, Jeong-kyu,Mazur, Sharlyn,Iera, Jaclyn A.,Phillips, Darren C.,Zambetti, Gerard P.,Appella, Daniel H.
supporting information; experimental part, p. 2429 - 2434 (2010/02/28)
Cancer cells evade death by over-producing specific proteins that inhibit apoptosis. One such group of proteins is the Bcl-2 family, of which Bcl-xL is an important member. This protein binds and inhibits BAK, another protein that promotes apop
Bioisosteric modification of PETT-HIV-1 RT-Inhibitors: Synthesis and biological evaluation
Hoegberg, Marita,Engelhardt, Per,Vrang, Lotta,Zhang, Hong
, p. 265 - 268 (2007/10/03)
Bioisosteric substitution of the thiourea (3, 5, 7, 9) and urea (10) moiety of PETT compounds with sulfamide (1), cyanoguanidine (2, 4) and guanidine (6, 8) functionalities, and replacement of the phenetyl group with benzolethyl group (compounds 11-20) ha
