7496-70-0Relevant academic research and scientific papers
Synthesis and biological evaluation of 2-aminothiazoles and their amide derivatives on human adenosine receptors. Lack of effect of 2-aminothiazoles as allosteric enhancers
Goeblyoes, Aniko,Santiago, Sabrina Neves,Pietra, Daniele,Mulder-Krieger, Thea,Kuenzel, Jacobien Von Frijtag Drabbe,Brussee, Johannes,Ijzerman, Adriaan P.
, p. 2079 - 2087 (2005)
A number of 2-aminothiazoles (2a-e) and their amide derivatives (4-10) were prepared. The 2-aminothiazoles themselves were tested as allosteric enhancers of agonist binding to human adenosine A1 receptors. In a variety of experimental set-ups the compounds did not show any such effect, in contrast to earlier findings by another research group. Subsequently the 2-aminothiazoles were used as intermediates in the synthesis of a number of amide derivatives of either aromatic (4-6) or aliphatic nature (7-10). Some of the compounds emerged as moderately active antagonists on human adenosine A1 and/or A 2A receptors with lower or negligible potency at adenosine A 3 receptors.
