7497-14-5

Upstream product

• 100-63-0 phenylhydrazine 
• 121-90-4 m-nitrobenzoic acid chloride 
• 71-43-2 benzene 
• 121-92-6 3-nitrobenzoic acid 
• 7539-23-3 1-(3-nitrobenzylidene)-2-phenylhydrazine 
• 59-88-1 phenylhydrazine hydrochloride 
• 83844-93-3 3-nitro-α-phenylazo-benzyl hydroperoxide 

Downstream Products

• 39209-19-3 3-nitro-N',N'-diphenylbenzohydrazide 

Relevant academic research and scientific papers

HYDRAZIDE DERIVATIVES AND THEIR SPECIFIC USE AS ANTIBACTERIAL AGENTS BY CONTROLLING ACINETOBACTER BAUMANNII BACTERIUM

The present invention relates to compounds of the following general formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, their use as a drug, in particular as antibacterial agent, notablyforpreventingand/or treating disorders associa

Copper(ii)-catalyzed coupling reaction: An efficient and regioselective approach to N′,N′-diaryl acylhydrazines

Using N′-aryl acylhydrazines as aryl donors, a novel copper(ii)-catalyzed homo-coupling reaction of N′-aryl acylhydrazines has been developed for the synthesis of N′,N′-diaryl acylhydrazines. We also provided a complementary procedure for the preparation of unsymmetrical diaryl acylhydrazines via cross-coupling reaction. These protocols featured mild reaction conditions, wide functional group tolerance and highly regioselective products. Control experiments indicated that this kind of coupling reaction might undergo a transient acyl diazene intermediate. This journal is

Oxidation of Sulfides by Acyclic α-Azohydroperoxides

The oxidation of sulfides with a series of substituted benzylazobenzene α-hydroperoxides (2a-f) produced the corresponding sulfoxides in good yield (ca. 90 percent) in C6D6 at 34 deg C.The reaction was found to be of the first order with respect to α-azohydroperoxide and to sulfide in aprotic medium.The reaction of BzSPh with acyclic α-azohydroperoxide 2a in C6D6 was found to be slower than the corresponding oxidation with 3-bromo -4,5-dihydro-5-hydroperoxy-4,4-dimethyl-3,5-diphenyl-3H-pyrazole in CDCl3.The relative reactivity series of sulfides with α-azohydroperoxide 2a was found to be Me2S (25)> BzSMe (14)> PhSMe (2.5)> BzSPh (1.0).This is similar to that observed for the reaction of the sulfides with hydrogen peroxide in protic solvent and reflects the relative nucleophilicities of the sulfides.The second-order rate constants for the reaction of a series of substituted benzylazobenzene α-hydroperoxides with PhSMe and BzSMe exhibited an excellent correlation with ? values.Both LFERs had ρ values of approximately 1.0.The results were interpreted to be consistent with nucleophilic attack of the sulfide on oxygen.Concomitant transfer of the hydroperoxy proton to the azo nitrogen would account for the lack of the requirement of general acid catalysis in aprotic medium.