7497-35-0Relevant academic research and scientific papers
4,6-Dimethylpyridine-2,3-dicarbonitrile and its reaction with N-acylhydrazines
Rudenko,Kucherak,Tolmachev,Hordiyenko
, p. 964 - 969 (2012/03/26)
An efficient method has been developed for the synthesis of 4,6-dimethylpyridine-2,3-dicarbonitrile. A study was carried out on the reaction of this compound with N-acylhydrazines to give two structural isomers, namely, N′-(7-amino-2,4-dimethyl-5H-pyrrolo[3,4-b]pyridin-5-ylidene) carbohydrazides and N′-(5-amino-2,4-dimethyl-7H-pyrrolo[3,4-b]pyridin-7- ylidene)carbohydrazides as well as disubstituted N′,N″-(2,4- dimethyl-5H-pyrrolo[3,4-b]pyridine-5,7-diylidene)dicarbohydrazides.
Magnesiation of pyridine N-oxides via iodine or bromine-magnesium exchange: A useful tool for functionalizing pyridine N-oxides
Duan, Xin-Fang,Zi-Qian, Ma.,Zhang, Fang,Zhang, Zhan-Bin
supporting information; experimental part, p. 939 - 942 (2009/06/20)
Iodo- or 2-bromopyridine N-oxides were readily magnesiated with i-PrMgCl ? LiCl via the iodine or bromine-magnesium exchange. The bromine adjacent to pyridine N-oxide (at the 2- or 6-position) can be regioselectively magnesiated in the presence of other position substituted halogens. This method was tested in various substituted pyridine N-oxide systems, and has been successfully applied to the total synthesis of caerulomycins E and A.
