- Isolation and structure elucidation of novel products of the acidic degradation of diazepam
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The acidic degradation of diazepam in methanolic aqueous solution has been investigated. Apart from the known degradation products, 2-(N-methylamino)- 5-chlorobenzophenone and glycine, produced by the hydrolytic cleavage of the benzodiazepinone ring, five novel products were isolated and fully characterized by their spectroscopic features and independent synthesis. Substituted 2-amino-3,5-dichlorobenzophenones and 2,4-dichloroacridinones were found, the formation of which in the reaction media is mechanistically intriguing. The rule of these unexpected products in accelerated studies of diazepam stability is discussed.
- Nudelman,De Waisbaum
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p. 208 - 211
(2007/10/02)
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