7497-92-9Relevant academic research and scientific papers
Novel compounds
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, (2008/06/13)
A compound of formula (I): STR1 or a salt, ester or amide thereof, in which Y is a group --O(CH2)m --, --(CH2)m -- or --CH=CH-- where m is an integer of from 1 to 5 n is an integer of from 4 to 14 X represents a double or triple bond, and each of A and B represents hydrogen when X is a double bond, or both A and B are absent when X is a triple bond, is useful in the treatment of allergic diseases.
Synthesis of Aryloxy Analogues of Arachidonic Acid via Wittig and Palladium Catalysed Cross-coupling Reactions
Buckle, Derek R.,Fenwick, Ashley E.,Outred, D. James,Rockell, Caroline J. M.
, p. 3144 - 3177 (2007/10/02)
The synthesis of o- and p-phenoxy analogues of arachidonic acid is described.In particular, the Wittig olefination reaction of hydroxy and alkyloxy benzaldehydes has been investigated and the products shown to be highly dependent on the solvent used.E/Z isomer control was difficult to achieve in most cases, although there was a tendency towards Z-isomer formation in dimethyl sulphoxide compared to tetrahydrofuran, particularly for the phenolic compounds.Specific Z-isomer formation was achieved by the partial reduction of alkynes derived from appropriately protected bromophenols via Heck or palladium catalysed cross-coupling reactions.
Synthesis of Peptide Alkaloids. 5. New Method for Synthesis of Ansa Peptides. Amino Acids and Peptides. 34
Schmidt, Ulrich,Lieberknecht, Albrecht,Griesser, Helmut,Talbiersky, Jorg
, p. 3261 - 3264 (2007/10/02)
Fourteen-membered para-ansa compounds and 13-membered meta-ansa compounds have been synthesized by catalytic hydrogenation of the pentafluorophenyl esters of ω-(Z)-amino carboxylic acids in 50percent and 80percent yields, respectively.
