74974-13-3

Upstream product

• 69729-07-3 H-Gly-Gly-Phe-Leu-OBzl 
• 112722-17-5 N-benzyloxycarbonyl-O-benzyltyrosine 2,6-dichloro-4-sulfenyl ester potassium salt 
• 1026430-54-5 C₂₉H₃₁NO₇ 
• 23234-86-8 N-(4-methoxybenzyloxycarbonyl)-L-phenylalanine 
• 86827-18-1 N-benzyloxycarbonyl-O-benzyl-L-tyrosine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 112695-92-8 Boc-Phe-OH 2,6-dibromo-4-sulfenyl ester sodium salt 
• 74193-68-3 N-tert-butyloxycarbonyl-L-phenylalanyl-L-leucine benzyl ester 
• 108379-22-2 Z(OMe)-Phe-OTAP 
• 98908-57-7 Z(OMe)-Gly-Phe-Leu-OBzl 
• 98908-56-6 Z(OMe)-Phe-Leu-OBzl 
• 98908-58-8 Z(OMe)-Gly-Gly-Phe-Leu-OBzl 
• 73994-89-5 (S)-benzyl 2-((S)-2-(2-aminoacetamido)-3-phenylpropanamido)-4-methylpentanoate 
• 63649-15-0 L-phenylalanyl-L-leucine benzyl ester 

Downstream Products

• 58822-25-6 Leu-enkephalin 

Relevant academic research and scientific papers

SYNTHESIS OF ENKEPHALINS BY THE METHOD OF POLYMERIC ACTIVATED ESTERS BASED ON 4-HYDROXY-3-NITROBENZOPHENONE

Leucine- and methionine-enkephalins have been synthesized by the successive growth of the peptide chain from the C-end by the method of polymeric activated esters based on 4-hydroxy-3-nitrobenzophenone with yields of 90 and 70percent, respectively, calculated on the initial C-terminal amino acid.Polystyrene with 2percent of divinylbenzene was used as the polymeric matrix.Using the synthesis of methionine-enkephalin as an example, the possibility has been shown of using polymeric activated esters for the synthesis of peptides with a free carboxy group.

AMINO ACIDS AND PEPTIDES. VIII. A WATER - SOLUBLE ACTIVE ESTER, PHENOLSULFONIC ACID DERIVATIVE

N-protected amino acid 4-phenolsulfonic acid derivative esters, such as 2,6-dibromo-4-sulfophenyl ester sodium salt, 2,6-dichloro-4-sulfophenyl ester potassium salt and 2-nitro-4-sulfophenyl ester sodium salt, were prepared.These esters are water - soluble active esters, and were applied for rhe synthesys of Leu-enkephalin.Keywords - water - soluble active ester; 2,6-dichloro-4-sulfophenyl ester; 2,6-dibromo-4-sulfophenyl ester; 2-nitro-4-sulfophenyl ester; peptide synthesis; Leu-enkephalin

AMINO ACIDS AND PEPTIDES. VII. PREPARATION AND APPLICATION OF A WATER-SOLUBLE ACTIVE ESTER, p-TRIMETHYLAMMONIOPHENYL ESTER

A water-soluble active ester, p-trimethylammoniophenyl ester iodide, and its nitro derivative were prepared from N-procteted amino acid and the corresponding phenol derivative by the dicyclohexylcarbodiimide method.The synthetic esters were applied to the synthesis of Leuenkephalin.Keywords--water-soluble active ester; p-trimethylammoniophenyl ester iodide; Leuenkephalin; peptide synthesis