63649-15-0

Basic information

• Product Name: L-Leucine, N-L-phenylalanyl-, phenylmethyl ester
• Synonyms: H-Phe-Leu-OBzl;Phe-Leu-OBn;Phe-LeuOBzl*HCl;Phe-Leu-OBzl;phenylalanyl-leucine benzyl ester
• CAS NO: 63649-15-0
• Molecular Formula: C22H28N2O3
• Molecular Weight: 368.476
• Mol File: 63649-15-0.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-L-phenylalanyl-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-L-phenylalanyl-, phenylmethyl ester(63649-15-0)
• EPA Substance Registry System: L-Leucine, N-L-phenylalanyl-, phenylmethyl ester(63649-15-0)

Safety Data

• Hazardous Substances Data: 63649-15-0(Hazardous Substances Data)

Usage

General Description

L-Leucine, N-L-phenylalanyl-, phenylmethyl ester is a chemical compound with the formula C20H24N2O3. It is an ester of the amino acid L-leucine and N-L-phenylalanyl. L-Leucine, N-L-phenylalanyl-, phenylmethyl ester is commonly used in the field of biochemistry and pharmaceuticals for its potential applications in drug delivery and protein synthesis. It has been studied for its role in promoting muscle protein synthesis and is often included in sports supplements and nutrition products to aid in muscle recovery and growth. Additionally, this compound has shown potential in the development of novel drug delivery systems due to its unique properties and bioavailability. Overall, L-Leucine, N-L-phenylalanyl-, phenylmethyl ester is a versatile chemical with promising applications in the fields of medicine and biotechnology.

Upstream product

• 1738-69-8 L-Leucine benzyl ester 
• 88099-25-6 2-[2-(2-Chloro-3H-inden-1-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid benzyl ester 
• 35661-40-6 N-Fmoc L-Phe 
• 108379-22-2 Z(OMe)-Phe-OTAP 
• 23234-86-8 N-(4-methoxybenzyloxycarbonyl)-L-phenylalanine 
• 142955-48-4 (BOC)2Phe-F 
• 113568-21-1 (BOC)2Phe-OH 
• 134996-39-7 tert-butyl 2-(tert-butylsulfonyl)-2-(propenyloxycarbonyl)-L-phenylalaninate 
• 134996-29-5 2-(tert-butylsulfonyl)-2-propenyloxycarbonylphenylalanyl chloride 
• 134996-41-1 2-(t-Butylsulfonyl)-2-propenyloxycarbonyl-L-phenylalanine 
• 16874-17-2 L-phenylalanine tert-butyl ester 
• 103321-57-9 2S-flouren-9-ylmethoxycarbonylamino-3-phenylpropionyl chloride 
• 134996-53-5 (S)-4-Methyl-2-{(S)-2-[2-(2-methyl-propane-2-sulfonyl)-allyloxycarbonylamino]-3-phenyl-propionylamino}-pentanoic acid benzyl ester 
• 47672-25-3 N-trityl-L-phenylalanine 

Downstream Products

• 73994-88-4 Boc-Gly-Phe-Leu-OBzl 
• 69729-07-3 H-Gly-Gly-Phe-Leu-OBzl 
• 124482-87-7 Fmoc-Gly-Gly-Phe-Leu-OBzl 
• 88099-29-0 Fmoc-Tyr(Bzl)-Gly-Gly-Phe-Leu-OBzl 
• 73994-89-5 (S)-benzyl 2-((S)-2-(2-aminoacetamido)-3-phenylpropanamido)-4-methylpentanoate 
• 100930-01-6 Tyr-Gly-Gly-Phe-Leu formate 
• 58822-25-6 Leu-enkephalin 
• 60254-86-6 Tyr-Gly-Gly-Phe-Leu 
• 69729-14-2 benzyl ester of N-tert-butoxycarbonylglycylglycylphenylalanylleucine 
• 77511-32-1 5>-enkephalin 
• 948314-83-8 Leu⁵-Eukephalin 
• 3303-55-7 L-Phe-Leu 
• 102307-07-3 N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine benzyl ester 
• 148797-60-8 Adoc₂-Gly-Phe-Leu-OBzl 

Relevant articles and documents

The photoredox-catalyzed hydrosulfamoylation of styrenes and its application in the novel synthesis of naratriptan

The hydrosulfamoylation of diverse aryl olefins provides facile access to alkylsulfonamides. Here we report a novel protocol utilizing radical-mediated addition and a thiol-assisted strategy to achieve the hydrosulfamoylation of diverse styrenes in modest to excellent yields under mild and economic reaction conditions. The methodology was found to provide an efficient and convenient approach for the synthesis of the anti-migraine drug naratriptan and it also can be used for the late-stage functionalization of natural products or medicines.

Amino-protecting groups subject to deblocking under conditions of nucleophilic addition to a Michael acceptor. Structure-Reactivity studies and use of the 2-(tert-Butylsulfonyl)-2-propenyloxycarbonyl (Bspoc) group

A new type of amino-protecting group is described in which a Michael acceptor is incorporated into the protectant so that treatment with a nucleophile will trigger deblocking. Comparison of various Michael acceptors showed that for several key electron-withdrawing groups, the order of reactivity was C6H5SO2 > Me3CSO2 > COOEt > C6H5SO > C6H4NO2-p. The reactivity of the nucleophile (e.g., primary and secondary aliphatic amines) followed an order related to both intrinsic basicity and steric effects. β- Substituents in the Michael acceptor caused significant retardation of the deblocking process. The Bspoc function was chosen for initial elaboration into a practical system for use in peptide synthesis. Bspoc amino acid chlorides were used as coupling agents and silica-tethered secondary amines as deblocking agents. With the latter, deblocking occurs cleanly and no byproducts remain in the organic solvent in which the deblocking is executed.

Synthesis of 15N-labelled Leu-enkephalins.

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