74976-75-3Relevant academic research and scientific papers
A Simple Approach to the Bicycloundecane System Present in Taxanes
Saha, Goutam,Karpha, Atashi,Roy, Supti Saha,Ghosh, Subrata
, p. 1587 - 1592 (2007/10/02)
A simple route for the synthesis of the bicycloundecane ring system present in taxanes has been developed.The key steps involve the cleavage of a carbon-carbon bond in the tricyclo2,6>decane system 5 and a one-carbon ring enlargement of the latter to the bicycloundecane system 23.The potential generality of this ring cleavage process has been examined using various tricyclo2,6>decane derivatives 5, 10 and 13 which have been prepared either through a cycloaddition reaction or by annelation via alkylation of the vicinal dianion.The scope and limitations of both these routes to the synthesis of the tricyclo2,6>decane derivatives have been demonstrated.
