7498-31-9Relevant articles and documents
Quinazoline antifolate thymidylate synthase inhibitors: Difluoro- substituted benzene ring analogues
Thornton,Jackman,Marsham,O'Connor,Bishop,Calvert
, p. 2321 - 2327 (2007/10/02)
The synthesis of a series of new C2-methyl-N10-alkylquinazoline-based thymidylate synthase (TS) inhibitors containing difluorinated p-aminobenzoate rings is described. Derivatives of the N10-propargyl and N10- m