7499-88-9

Basic information

• Product Name: 3-benzyl-1,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione
• CAS NO: 7499-88-9
• Molecular Formula: C₁₄H₁₄N₄O₂
• Molecular Weight: 270.2866
• Mol File: 7499-88-9.mol

Chemical Properties

• Boiling Point: 515.8°C at 760 mmHg
• Flash Point: 265.7°C
• Density: 1.33g/cm³
• Vapor Pressure: 9.56E-11mmHg at 25°C
• Refractive Index: 1.67
• CAS DataBase Reference: 3-benzyl-1,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzyl-1,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione(7499-88-9)
• EPA Substance Registry System: 3-benzyl-1,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione(7499-88-9)

Safety Data

• Hazardous Substances Data: 7499-88-9(Hazardous Substances Data)

Upstream product

• 19844-93-0 3-Benzylxanthine 
• 74-88-4 methyl iodide 
• 64995-73-9 3-benzyl-7-methyl-1H-purine-2,6(3H,7H)-dione 
• 611-59-6 paraxanthine 
• 100-39-0 benzyl bromide 
• 64995-66-0 4-(N-benzylamino)-1-methyl-1H-imidazole-5-carboxamide 

Downstream Products

• 611-59-6 paraxanthine 
• 139927-95-0 3-<(4-methoxymethoxy)-3-nitrobenzyl>-1,7-dimethylxanthine 
• 139927-96-1 3-(4-hydroxy-3-nitrobenzyl)-1,7-dimethylxanthine 

Relevant articles and documents

Preparation method of 1,7-dimethylxanthine

The invention provides a preparation method of 1,7-dimethylxanthine. The method specifically includes firstly, a compound (III) reacts with a methylation reagent in a certain solvent in the presence or absence of alkali to obtain a compound (II); secondly

Purines. XLIX. Synthesis and proton nuclear magnetic resonance study of 3,7-dialkylxanthines and 1,3,7-trialkylxanthines

A general synthetic route to 3,7-dialkylxanthines (type 9) from 3,7-dialkyladenines (6) [hence from 3- or 7-alkyladenines (11 or 10)] has been established. The route started with ethoxycarbonylation of 1-alkyl-4-(alkylamino)1H-imidazole-5-carboxamides (7), readily obtainable from 6 by alkaline hydrolysis, and proceeded through cyclization of the resulting carbamates (8) under alkaline conditions. Alkylation of 9 with alkyl halide in N,N-dimethylformamide in the presence of anhydrous K2CO3 extended the above synthetic route to the 1,3,7-trialkylxanthine level (type 14). Hydrogenolytic deb nzylation of 3-benzyl-1,7-dimethylxanthine (16), prepared by following this general synthetic route, furnished paraxanthine (26) in fair yield. Conversion of 26 into 3-(4-hydroxy-3-nitrobenzyl)-1,7-dimethylxanthine (24), isomeric with the bryozoan purine phidolopin (2), was effected through aralkylation with 4-(methoxymethoxy)-3-nitrobenzyl bromide (28) followed by O-deprotection. On the basis of proton nuclear magnetic resonance data for the 3,7-dialkylxanthines (3 and 9b-i) and 1,3,7-trialkylxanthines (5 and 14-22) thus prepared, reliable criteria for distinguishing signals of N-alkyl substituents at various positions are put forward.

SUBSTITUTED XANTHINES AND CYTOKININ ANALOGUES AS INHIBITORS OF CYTOKININ N-GLUCOSYLATION

A series of 3-substituted xanthines, 2-(2-hydroxy-2-methylpropylamino)-9-methyl-6-benzylaminopurine and 7-benzylaminooxazolopyrimidine were synthesized as potential inhibitors of cytokinin N-glucosylation.In maize leaf segments the latter compound