749925-30-2

Upstream product

• 906463-15-8 6-(2-chloro-phenyl)-5-methyl-pyridin-3-ylamine 
• 906463-06-7 2-(2-chloro-phenyl)-3-methyl-5-nitro-pyridine 
• 444664-42-0 4,6-dibromo-2-(2-chlorophenyl)-3-methylpyridine 
• 906463-07-8 2,4-dibromo-6-(2-chloro-phenyl)-5-methyl-pyridin-3-ylamine 
• 444665-07-0 4,6-Dibromo-3-(bromomethyl)-2-(2-chlorophenyl)pyridine 
• 3900-89-8 2-Chlorobenzeneboronic acid 
• 22280-56-4 2-chloro-3-methyl-5-nitropyridine 
• 749925-29-9 3-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-yl]-propionic acid tert-butyl ester 

Downstream Products

• 444665-14-9 tert-butyl 4-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl]-3,6-dihydropyridine-1(2 H)-carboxylate 
• 444665-15-0 tert-butyl 4-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl]piperidine-1-carboxylate 
• 527680-15-5 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-1,6-naphthyridin-2(1H)-one 
• 444665-16-1 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-piperidin-4-yl-1,6-naphthyridin-2(1H)-one 
• 527680-14-4 3-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-yl]-N-(2,6-dichloro-phenyl)-propionamide 
• 444665-06-9 7-bromo-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-1,6-naphthyridin-2(1H)-one 
• 444665-10-5 7-bromo-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-one 

Relevant academic research and scientific papers

p38 inhibitors: Piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones

We have synthesized a series of C7-piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones that are highly potent inhibitors of both p38 MAP kinase activity and TNF-α release. The 4-aminopentamethylpiperidin