906463-06-7

Usage

Molecular Structure

Consists of a pyridine ring with a nitro group at the 5th position, a methyl group at the 3rd position, and a chloro-phenyl group at the 2nd position.

Physical State

Yellow solid.

Solubility

Soluble in organic solvents.

Uses

Used in the synthesis of pharmaceuticals and agrochemical products.

Potential Biological Activities

May have potential biological activities, making it valuable in medicinal chemistry research.

Handling Precautions

Should be handled with care due to its potential hazardous properties.

Upstream product

• 22280-56-4 2-chloro-3-methyl-5-nitropyridine 
• 3900-89-8 2-Chlorobenzeneboronic acid 

Downstream Products

• 906463-15-8 6-(2-chloro-phenyl)-5-methyl-pyridin-3-ylamine 
• 444665-14-9 tert-butyl 4-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl]-3,6-dihydropyridine-1(2 H)-carboxylate 
• 444665-15-0 tert-butyl 4-[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl]piperidine-1-carboxylate 
• 527680-15-5 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperidin-4-ylamino)-1,6-naphthyridin-2(1H)-one 
• 444665-16-1 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-piperidin-4-yl-1,6-naphthyridin-2(1H)-one 
• 527680-14-4 3-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-yl]-N-(2,6-dichloro-phenyl)-propionamide 
• 444665-06-9 7-bromo-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydro-1,6-naphthyridin-2(1H)-one 
• 444665-10-5 7-bromo-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-one 
• 749925-29-9 3-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-yl]-propionic acid tert-butyl ester 
• 749925-30-2 3-[4,6-dibromo-2-(2-chloro-phenyl)-pyridin-3-yl]-propionic acid 
• 906463-07-8 2,4-dibromo-6-(2-chloro-phenyl)-5-methyl-pyridin-3-ylamine 
• 444665-07-0 4,6-Dibromo-3-(bromomethyl)-2-(2-chlorophenyl)pyridine 
• 444664-42-0 4,6-dibromo-2-(2-chlorophenyl)-3-methylpyridine 
• 906463-12-5 4-[5-(2-chloro-phenyl)-1-(2,6-dichloro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrido[4,3-d]pyrimidin-7-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones

p38 inhibitors based on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-one and 3,4-dihydropyrido[4,3-d]pyrimidin-2-one platforms were synthesized and preliminary SAR explored. Among the pyrimido-pyrimidones the emergence of two sub-types of analogs-C7-amino-pyrimi

p38 inhibitors: Piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones

We have synthesized a series of C7-piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones that are highly potent inhibitors of both p38 MAP kinase activity and TNF-α release. The 4-aminopentamethylpiperidin