749929-08-6Relevant academic research and scientific papers
Concise total synthesis of (±)-pisiferin
Li, Yulong,Li, Liqi,Guo, Yueming,Xie, Zhixiang
, p. 9282 - 9286 (2015)
A concise total synthesis of (±)-pisiferin has been accomplished from commercially available compounds α-cyclocitral (9) and 4-bromo-2-isopropylphenol (10) via Suzuki coupling and F-C alkylation as key reaction in five steps with an overall yield of 22%. The feature of this concise synthesis is a convergent strategy coupled by Suzuki reaction. This work not only provides a strategy to approach the total synthesis of pisiferin itself but also serves as an additional correlation origin to which many related icetaxane-type diterpenes can be referred.
INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME
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Page 126, (2008/06/13)
The invention relates to compounds of the formula (I) and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula (I), and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula (I). The invention also relates to methods of preparing the compounds of formula (I).
