7500-53-0

Usage

Uses

Used in Pharmaceutical Industry:
1,2-Phenylenediacetic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of novel drugs with specific therapeutic properties.
Used in Cancer Research:
1,2-Phenylenediacetic acid is used as a precursor in the preparation of nanomolar inhibitors of cancer-relevant transcription factor STAT5b. These inhibitors have the potential to target and suppress the activity of STAT5b, which plays a crucial role in the growth and survival of cancer cells. By inhibiting STAT5b, these compounds can help in the development of new cancer therapies and contribute to the fight against various types of cancer.

InChI:InChI=1/C10H10O4/c11-9(12)5-7-3-1-2-4-8(7)6-10(13)14/h1-4H,5-6H2,(H,11,12)(H,13,14)/p-2

Upstream product

• 111-65-9 octane 
• 95-47-6 o-xylene 
• 1822-71-5 n-pentylsodium 
• 35583-15-4 cis-1,2,3,4-tetrahydro-naphthalene-2,3-diol 
• 200724-92-1 2-oxo-indan-1-carbonitrile 
• 613-73-0 1,2-phenylenediacetonitrile 
• 58891-37-5 2-oxo-indan-1-carboxylic acid ethyl ester 
• 7664-93-9 sulfuric acid 
• 6970-78-1 1,2,3,4-tetrahydro-naphthalene-2,3-diol 
• 189242-48-6 2-amino-3H-indene-1-carbonitrile 
• 1559-81-5 1-methyl-1,2,3,4-tetrahydronaphthalene 
• 91-13-4 α,α'-dibromo-o-xylene 
• 855654-81-8 (2-carboxymethyl-phenyl)-malonic acid 
• 7500-54-1 o-xylylenediamide 

Downstream Products

• 19109-69-4 (o-Phenylen)bis(essigsaeure-methylester) 
• 93439-58-8 o-phenylenedioxydiacetic acid 
• 91057-81-7 cyclohexane-1,2-diyldi-acetic acid 
• 408321-10-8 diethyl αα'-dibromobenzene-1,2-diacetate 
• 102441-53-2 o-phenylene-di-acetic acid dianilide 
• 615-13-4 2-indanone 
• 100875-76-1 o-phenylenedi-acetic acid bis-dimethylamide 
• 17532-66-0 ethyl 2-[2-(2-ethoxy-2-oxoethyl)phenyl]acetate 
• 154459-07-1 (S)-2-(2-{2-[((S)-1-Methoxycarbonyl-2-methyl-propylcarbamoyl)-methyl]-phenyl}-acetylamino)-3-methyl-butyric acid methyl ester 
• 154459-08-2 (S)-2-(2-{2-[((S)-1-Methoxycarbonyl-2-phenyl-ethylcarbamoyl)-methyl]-phenyl}-acetylamino)-3-phenyl-propionic acid methyl ester 
• 17378-99-3 2,2’-(1,2-phenylene)diethanol 
• 2184-00-1 2,4-Dioxo-2,3,4,5-tetrahydro-1H-3-benzazepin 
• 863908-08-1 (3R,11aS)-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one 
• 863908-13-8 methyl (R)-2-{2-[N-(2-hydroxy-1-phenylethyl)carbamoylmethyl]phenyl}acetate 

Relevant academic research and scientific papers

Cobalt/N-Hydroxyphthalimide(NHPI)-Catalyzed Aerobic Oxidation of Hydrocarbons with Ionic Liquid Additive

A highly efficient and solvent-free system of cobalt/NHPI-catalyzed aerobic oxidation of hydrocarbons was developed using imidazolium-based ionic liquid (IL) as an additive. These amphipathic ILs were found self-assemble at the interface between the organic hydrocarbons and the aqueous phase of catalyst combination (Co/NHPI), with forming a solution of reversed multilamellar vesicles for catalysis. The initial reaction rate was influenced by both the composition of microdomains and the structure of IL launched. Consequently, a proper water content (χH2O) of wet IL was requisite to reach the optimum reactivity. Besides, the interfacial boundary between aqueous and organic phase composed by C2-alkylated imidazolium ILs, such as [bdmim]SbF6 and [C12dmim]SbF6, not only has ternary aggregates (hydrocarbons/IL/H2O) of higher stability but renders O2 a faster diffusion rate and higher concentration, thereby offering a high reactivity of the protocol towards hydrocarbon oxidation.

PHENYLENE OXO-DIESTER PLASTICIZERS AND METHODS OF MAKING

A process for making non-phthalate, 1,2-phenylene oxo-diester plasticizers for polymer compositions, by selectively hydrogenating naphthalene to form a partially hydrogenated naphthalene, oxygenating said partially hydrogenated naphthalene to form phenylene diacids, and esterifying said phenylene diacids with oxo-alcohols to form 1,2-phenylene oxo-diesters. Also a process for making phenylene oxo-diester plasticizers by selectively brominating xylenes to form bisbromomethylbenzene, catalytic carboalkoxylation of the bromo-compound to form phenylene diacetate, followed by transesterification to form the phenylene oxo-diester.

2-aminoindane analogs

The present invention relates to therapeutically active 2-aminoindane analogs of formula (I): Also provided is a method of preparing compounds of formula (I), and pharmaceutical compositions comprising the compounds. The novel compounds act as modulators of metabotropic glutamate receptors and, as such, are useful in treating diseases of the central nervous system related to the metabotropic glutamate receptor system.

A NEW PHOTO/THERMOCHROMIC SOLID COMPOUND OF THE INDENONE OXIDE FAMILY

A new strong photochromic solid compound, a 3-ketone of the 2,3-diphenylindenone oxide, has been prepared for first time.The new compound exhibits very strong photochromic and thermochromic phenomena.