7500-53-0

Basic information

• Product Name: 1,2-Phenylenediacetic acid
• Synonyms: BENZENE-1,2-DIACETIC ACID;1,2-PHENYLENEDIACETIC ACID;RARECHEM AL BO 0119;O-PHENYLENEDIACETIC ACID;O-BENZENEDIACETIC ACID;2-Phenylenediacetic acid;o-Phenylenediacetic acid, 98+%;1,2-Benzenediacetic acid
• CAS NO: 7500-53-0
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.18
• EINECS: 231-355-1
• Product Categories: Aromatic Phenylacetic Acids and Derivatives;C10;Carbonyl Compounds;Carboxylic Acids
• Mol File: 7500-53-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 150-152 °C(lit.)
• Boiling Point: 290.62°C (rough estimate)
• Flash Point: 210.9 °C
• Appearance: Beige to beige-brown/Needle-Like Crystalline Powder
• Density: 1.2534 (rough estimate)
• Vapor Pressure: 3.59E-07mmHg at 25°C
• Refractive Index: 1.5430 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.90±0.10(Predicted)
• BRN: 2616747
• CAS DataBase Reference: 1,2-Phenylenediacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Phenylenediacetic acid(7500-53-0)
• EPA Substance Registry System: 1,2-Phenylenediacetic acid(7500-53-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 7500-53-0(Hazardous Substances Data)

Usage

Chemical Properties

beige to beige-brown needle-like crystalline

Uses

1,2-Phenylenediacetic Acid has been used in the preparation of nanomolar inhibitors of cancer-relevant transcription factor STAT5b.

General Description

A coordination polymer with 1,2-Phenylenediacetic acid was synthesized and characterized by single crystal X-ray diffraction.

InChI:InChI=1/C10H10O4/c11-9(12)5-7-3-1-2-4-8(7)6-10(13)14/h1-4H,5-6H2,(H,11,12)(H,13,14)/p-2

Upstream product

• 111-65-9 octane 
• 95-47-6 o-xylene 
• 1822-71-5 n-pentylsodium 
• 613-73-0 1,2-phenylenediacetonitrile 
• 1559-81-5 1-methyl-1,2,3,4-tetrahydronaphthalene 
• 189242-48-6 2-amino-3H-indene-1-carbonitrile 
• 91-13-4 α,α'-dibromo-o-xylene 
• 7664-93-9 sulfuric acid 
• 6970-78-1 1,2,3,4-tetrahydro-naphthalene-2,3-diol 
• 200724-92-1 2-oxo-indan-1-carbonitrile 
• 58891-37-5 2-oxo-indan-1-carboxylic acid ethyl ester 
• 855654-81-8 (2-carboxymethyl-phenyl)-malonic acid 
• 7500-54-1 o-xylylenediamide 
• 17532-66-0 ethyl 2-[2-(2-ethoxy-2-oxoethyl)phenyl]acetate 

Downstream Products

• 91057-81-7 cyclohexane-1,2-diyldi-acetic acid 
• 156589-80-9 (E)-2-[2-[3-[2-[4-(1-methylethyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzeneacetic acid 
• 156589-79-6 (E)-2-[2-[3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzeneacetic acid 
• 1055380-42-1 [Ni(di(4-pyridyl)amine)(1,2-phenylenediacetate)(H₂O)]n 
• 1100055-00-2 [Zn(1,2-phenylenediacetate)(2,2'-bipyridyl)(water)]n 
• 1100055-01-3 [Zn(1,2-phenylenediacetic acid(-H))2(2,2'-bipyridyl)] 
• 1283145-28-7 [Cd(μ-1,2-phenylenediacetate)(1,4-bis(imidazol-1-ylmethyl)benzene)]_n 
• 1312597-87-7 [Co(ortho-phenylenediacetate)(4,4-bipyridine)] 
• 1258402-00-4 (2,2'-(1,2-phenylene)diacetate)(5,6-dimethyl-1H-benzoimidazole)aquacobalt(II) 
• 72686-12-5 2-[2-(2-oxo-2-phenylethyl)phenyl]acetic acid 
• 1092964-60-7 2-[2-(2-oxobutyl)phenyl]acetic acid 
• 1092964-61-8 2-[2-(2-oxohexyl)phenyl]acetic acid 
• 68850-07-7 1,2-bis(1-hydroxyethyl)benzene 

Relevant articles and documents

Cobalt/N-Hydroxyphthalimide(NHPI)-Catalyzed Aerobic Oxidation of Hydrocarbons with Ionic Liquid Additive

A highly efficient and solvent-free system of cobalt/NHPI-catalyzed aerobic oxidation of hydrocarbons was developed using imidazolium-based ionic liquid (IL) as an additive. These amphipathic ILs were found self-assemble at the interface between the organic hydrocarbons and the aqueous phase of catalyst combination (Co/NHPI), with forming a solution of reversed multilamellar vesicles for catalysis. The initial reaction rate was influenced by both the composition of microdomains and the structure of IL launched. Consequently, a proper water content (χH2O) of wet IL was requisite to reach the optimum reactivity. Besides, the interfacial boundary between aqueous and organic phase composed by C2-alkylated imidazolium ILs, such as [bdmim]SbF6 and [C12dmim]SbF6, not only has ternary aggregates (hydrocarbons/IL/H2O) of higher stability but renders O2 a faster diffusion rate and higher concentration, thereby offering a high reactivity of the protocol towards hydrocarbon oxidation.

2-aminoindane analogs

The present invention relates to therapeutically active 2-aminoindane analogs of formula (I): Also provided is a method of preparing compounds of formula (I), and pharmaceutical compositions comprising the compounds. The novel compounds act as modulators of metabotropic glutamate receptors and, as such, are useful in treating diseases of the central nervous system related to the metabotropic glutamate receptor system.