58891-37-5

Upstream product

• 613-73-0 1,2-phenylenediacetonitrile 
• 17532-66-0 ethyl 2-[2-(2-ethoxy-2-oxoethyl)phenyl]acetate 
• 71-43-2 benzene 
• 141-52-6 sodium ethanolate 

Downstream Products

• 615-13-4 2-indanone 
• 1126602-63-8 N₄-(4-chloro-2-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine 
• 1126602-62-7 N₄-(3-chloro-4-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine 
• 1126602-59-2 N₄-(3-methoxyphenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine 
• 1126602-58-1 N₄-(4-(trifluoromethyl)phenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine 
• 1126602-57-0 N₄-(4-bromophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine 
• 1126602-61-6 N₄-(3-bromophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine 
• 1126602-56-9 N₄-(4-chlorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine 
• 1126602-54-7 N₄-(3-chlorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine 
• 1126602-55-8 N₄-(4-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine 
• 1126602-53-6 N₄-(3-fluorophenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine 
• 1126602-52-5 N₄-(4-isopropylphenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine 
• 1126602-51-4 N₄-(2-isopropylphenyl)-9H-indeno[2,1-d]pyrimidine-2,4-diamine 
• 1126602-60-5 N₄-phenyl-9H-indeno[2,1-d]pyrimidine-2,4-diamine 

Relevant academic research and scientific papers

Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents

We designed, synthesized and evaluated 13 novel tricyclic indeno[2,1-d]pyrimidines as RTK inhibitors. These analogues were synthesized via a Dieckmann condensation of 1,2-phenylenediacetonitrile followed by cyclocondensation with guanidine carbonate to af

TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF

The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase inhibitory activity, which are useful as anti-angiogenic and anti-tumor agents. Also provided are methods of utilizing these inhibitors to treat tumor cells and other proliferative diseases and disorders.

Benzobicycloalkane ketones

Benzobicycloalkane amines, their pharmacologically acceptable addition salts, intermediates therefore the processes for their preparation and use. The compounds of the invention exert analgesic and anti-inflammatory activity.

Benzobicycloalkanone oximes

Benzobicycloalkanone oximes which are intermediates for the preparation of benzobicycloalkane amines. The amines exert analgesic and antiinflammatory effects in warm-blooded animals.