75000-25-8

Basic information

• Product Name: 2-(2-(4-(2-methylphenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione
• Synonyms: 2-(2-(4-(2-methylphenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione
• CAS NO: 75000-25-8
• Molecular Weight: 349.433
• Mol File: 75000-25-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(2-(4-(2-methylphenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(4-(2-methylphenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione(75000-25-8)
• EPA Substance Registry System: 2-(2-(4-(2-methylphenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione(75000-25-8)

Safety Data

• Hazardous Substances Data: 75000-25-8(Hazardous Substances Data)

Upstream product

• 574-98-1 2-(2-bromoethyl)isoindoline-1,3-dione 
• 39512-51-1 1-(o-toluyl)piperazine 

Downstream Products

• 1608157-07-8 2-(furan-2-yl)-N⁵-(2-(4-(2-methyphenyl)piperazin-1-yl)ethyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine 
• 58334-09-1 2-(4-o-tolyl-piperazin-1-yl)-ethylamine 

Relevant articles and documents

Binding kinetics of ZM241385 derivatives at the human adenosine A 2A receptor

Classical drug design and development rely mostly on affinity- or potency-driven structure-activity relationships (SAR). Thus far, a given compound's binding kinetics have been largely ignored, the importance of which is now being increasingly recognized. In the present study, we performed an extensive structure-kinetics relationship (SKR) study in addition to a traditional SAR analysis at the adenosine A2A receptor (A 2AR). The ensemble of 24 A2AR compounds, all triazolotriazine derivatives resembling the prototypic antagonist ZM241385 (4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino) ethyl)phenol), displayed only minor differences in affinity, although they varied substantially in their dissociation rates from the receptor. We believe that such a combination of SKR and SAR analyses, as we have done with the A 2AR, will have general importance for the superfamily of G protein-coupled receptors, as it can serve as a new strategy to tailor the interaction between ligand and receptor. Above and beyond: Insight into the binding kinetics of ZM241385 derivatives at the human adenosine A2A receptor has provided additional information beyond a traditional structure-activity relationship (SAR) analysis. The strategy, combining a structure-kinetics relationship investigation and SAR, can serve as an important tool for more directed medicinal chemistry efforts in the future.

Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers

T-type calcium channel is one of therapeutic targets for the treatment of cardiovascular diseases and neuropathic pain. In this study, as a part of our ongoing efforts to develop potent T-type calcium channel blockers, we designed oxazole derivatives subs