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58334-09-1

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58334-09-1 Usage

General Description

2-(4-o-tolyl-piperazin-1-yl)-ethylamine, also known as 4-(2-aminoethyl)-1-piperazineethanol, is a chemical compound with the molecular formula C13H22N2O. It is a piperazine derivative that contains both an ethylamine and a piperazine moiety. 2-(4-o-tolyl-piperazin-1-yl)-ethylamine has been studied for its potential use as a neuroprotective agent, particularly in the treatment of neurodegenerative diseases such as Parkinson's and Alzheimer's. Additionally, 2-(4-o-tolyl-piperazin-1-yl)-ethylamine has also demonstrated antidepressant and anxiolytic properties in preclinical studies, making it a potential candidate for the development of novel psychiatric medications. Further research is needed to fully understand the pharmacological and therapeutic potential of this compound.

Check Digit Verification of cas no

The CAS Registry Mumber 58334-09-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,3,3 and 4 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 58334-09:
(7*5)+(6*8)+(5*3)+(4*3)+(3*4)+(2*0)+(1*9)=131
131 % 10 = 1
So 58334-09-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H21N3/c1-12-4-2-3-5-13(12)16-10-8-15(7-6-14)9-11-16/h2-5H,6-11,14H2,1H3

58334-09-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[4-(2-methylphenyl)piperazin-1-yl]ethanamine

1.2 Other means of identification

Product number -
Other names 2-(4-o-tolyl-piperazin-1-yl)-ethylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:58334-09-1 SDS

58334-09-1Relevant articles and documents

Binding kinetics of ZM241385 derivatives at the human adenosine A 2A receptor

Guo, Dong,Xia, Lizi,Van Veldhoven, Jacobus P. D.,Hazeu, Marc,Mocking, Tamara,Brussee, Johannes,Ijzerman, Adriaan P.,Heitman, Laura H.

, p. 752 - 761 (2014/05/06)

Classical drug design and development rely mostly on affinity- or potency-driven structure-activity relationships (SAR). Thus far, a given compound's binding kinetics have been largely ignored, the importance of which is now being increasingly recognized. In the present study, we performed an extensive structure-kinetics relationship (SKR) study in addition to a traditional SAR analysis at the adenosine A2A receptor (A 2AR). The ensemble of 24 A2AR compounds, all triazolotriazine derivatives resembling the prototypic antagonist ZM241385 (4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino) ethyl)phenol), displayed only minor differences in affinity, although they varied substantially in their dissociation rates from the receptor. We believe that such a combination of SKR and SAR analyses, as we have done with the A 2AR, will have general importance for the superfamily of G protein-coupled receptors, as it can serve as a new strategy to tailor the interaction between ligand and receptor. Above and beyond: Insight into the binding kinetics of ZM241385 derivatives at the human adenosine A2A receptor has provided additional information beyond a traditional structure-activity relationship (SAR) analysis. The strategy, combining a structure-kinetics relationship investigation and SAR, can serve as an important tool for more directed medicinal chemistry efforts in the future.

Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers

Lee, Jie Eun,Koh, Hun Yeong,Seo, Seon Hee,Baek, Yi Yeon,Rhim, Hyewhon,Cho, Yong Seo,Choo, Hyunah,Pae, Ae Nim

scheme or table, p. 4219 - 4222 (2010/09/04)

T-type calcium channel is one of therapeutic targets for the treatment of cardiovascular diseases and neuropathic pain. In this study, as a part of our ongoing efforts to develop potent T-type calcium channel blockers, we designed oxazole derivatives subs

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