75001-18-2Relevant academic research and scientific papers
A New Vinylic Organolithium Reagent: An Expedient C10 + C10 Synthesis of Retinal
Duhamel, L.,Duhamel, P.,Gallic, Y. Le
, p. 319 - 322 (1993)
2,6-Dimethyl-8-methoxy-1-lithio-octatetra-1,3,5,7-ene 4 is prepared by bromine-lithium exchange from its readily accessible bromo precursor 8.The lithio reagent 4 reacts with carbonyl compounds to give in one pot, after a mild acidic hydrolysis, the retinoid aldehydes 2.
