Tetrahedron Letters p. 319 - 322 (1993)
Update date:2022-08-04
Topics:
Duhamel, L.
Duhamel, P.
Gallic, Y. Le
2,6-Dimethyl-8-methoxy-1-lithio-octatetra-1,3,5,7-ene 4 is prepared by bromine-lithium exchange from its readily accessible bromo precursor 8.The lithio reagent 4 reacts with carbonyl compounds to give in one pot, after a mild acidic hydrolysis, the retinoid aldehydes 2.
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