75002-35-6

Upstream product

• 58626-75-8 8-hydroxy-3,7-dimethyl-octa-2,4,6-trien-1-oic acid ethyl ester 
• 63826-41-5 2E,4E,6E-2,6-Dimethyl-7-ethoxycarbonyl-2,4,6-heptatrienal 
• 74479-57-5 8-bromo-3,7-dimethyl-octa-2,4,6-trien-1-oic acid ethyl ester 
• 603-35-0 triphenylphosphine 
• 6399-81-1 triphenylphosphine hydrobromide 
• 81121-26-8 (E)-3-[3-(2-Methyl-propenyl)-oxiranyl]-but-2-enoic acid ethyl ester 

Downstream Products

• 85079-44-3 Ethyl (+/-)-2E,4E,6Z,8E-3,7-dimethyl-9-(2,6-dimethyl-3-oxo-6-ethoxycarbonyl-1-cyclohexenyl)-2,4,6,8-nonatetraenoate 
• 85079-44-3 Ethyl (+/-)-2E,4E,6E,8E-3,7-dimethyl-9-(2,6-dimethyl-3-oxo-6-ethoxycarbonyl-1-cyclohexenyl)-2,4,6,8-nonatetraenoate 
• 127666-69-7 (2E,4E,6E,8E)-9-[2,6-Dimethyl-4-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid ethyl ester 

Relevant academic research and scientific papers

SYNTHETIC INVESTIGATIONS INTO THE CHEMISTRY OF POLYENE COMPOUNDS XLVII. TOTAL SYNTHESIS OF (+/-)-(2E,4E,6E,6Z,8E)-3,7-DIMETHYL-9-(2,6-DIMETHYL-3-OXO-6-ETHOXYCARBONYL-1-CYCLOHEXENYL)-2,4,6,8-NONATETRAENOIC ACID. THE WITTIG REACTION AT HIGH PRESURES

The synthesis of the C20 retinoids (+/-)-2E,4E,6E,6Z,8E-3,7-dimethyl-9-(2,6-dimethyl-3-oxo-6-ethoxycarbonyl-1-cyclohexenyl)-2,4,6,8-nonatetraenoic acid the previously undescribed ethyl (+/-)-2E,4Z,6E-2-isopropenyl-5-methyl-7-(2,6-dimethyl-3-oxo-6-ethoxycarbonyl-1-cyclohexenyl)-2,4,6-heptatrienoate was realized by the C10 + C10 to C20 scheme with the use of the Wittig reaction at high presure.