7501-44-2Relevant academic research and scientific papers
1,2-DIACYLGLYCEROL COMPOUND, PREPARATION METHOD THEREFOR, AND IMMUNOMODULATOR CONTAINING SAME AS ACTIVE INGREDIENT
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Paragraph 0040, (2021/01/26)
Disclosed are a novel 1,2-diacylglycerol compound that useful for improving, preventing or treating inflammation-related diseases by inhibiting overexpression of various inflammatory cytokines such as IL-4 and IL-6 or chemokine CXCL8 related to the migrat
GLYCEROL DERIVATIVE, PREPARATION METHOD THEREFOR, AND IMMUNOMODULATOR COMPRISING SAME AS EFFECTIVE INGREDIENT
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Paragraph 0072-0073, (2021/07/02)
Disclosed are a glycerol derivative that is useful for improving, preventing or treating inflammation-related diseases by inhibiting overexpression of various inflammatory cytokines such as IL-4, IL-6 and so on, or chemokine CXCL8 and reducing migration of HL-60 cell lines, preparation method therefor, and an immunomodulator containing the same as active ingredient. It includes a glycerol derivative represented by Chemical formula 2 or 3 in the specification.
Direct determination of MCPD fatty acid esters and glycidyl fatty acid esters in vegetable oils by LC-TOFMS
Haines, Troy D.,Adlaf, Kevin J.,Pierceall, Robert M.,Lee, Inmok,Venkitasubramanian, Padmesh,Collison, Mark W.
experimental part, p. 1 - 14 (2011/10/04)
Analysis of MCPD esters and glycidyl esters in vegetable oils using the indirect method proposed by the DGF gave inconsistent results when salting out conditions were varied. Subsequent investigation showed that the method was destroying and reforming MCPD during the analysis. An LC time of flight MS method was developed for direct analysis of both MCPD esters and glycidyl esters in vegetable oils. The results of the LC-TOFMS method were compared with the DGF method. The DGF method consistently gave results that were greater than the LC-TOFMS method. The levels of MCPD esters and glycidyl esters found in a variety of vegetable oils are reported. MCPD monoesters were not found in any oil samples. MCPD diesters were found only in samples containing palm oil, and were not present in all palm oil samples. Glycidyl esters were found in a wide variety of oils. Some processing conditions that influence the concentration of MCPD esters and glycidyl esters are discussed.
Bidirectional conversion between 3-monochloro-1,2-propanediol and glycidol in course of the procedure of DGF standard methods
Kaze, Naoki,Sato, Hirofumi,Yamamoto, Hiroshi,Watanabe, Yomi
experimental part, p. 1143 - 1151 (2011/11/12)
NMR observation revealed that bidirectional conversion occurred between 3-monochloropropane-1,2-diol (3-MCPD) and glycidol in the course of the analytical procedure of DFG standard method C-III 18 (09), option A; 3-MCPD was partly converted to glycidol at the transesterification step, and glycidol was converted partly to 3-MCPD at the derivatization step conducted at 80 °C under acidic condition in the presence of NaCl. Based on the proton numbers observed by 1H NMR, the degrees of the conversion were estimated to be 37 and >70%, respectively. In addition, epoxide ring-opening of glycidol and its esters was found to be ca. 90% by the acid treatment described in the method, option B. Thus, it was concluded that the standard method, option A, did not correctly give the combined amount of 3-MCPD esters and glycidyl esters in oils containing glycidyl esters, and the difference of the values obtained by options A and B did not correspond to the amount of glycidyl esters, either. In addition, derivatives of 3-MCPD with phenylboronic acid were not observed by NMR at the derivatization step, although they were detected by GC-MS in the organic phase at the following extraction step.
Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
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Page/Page column 47, (2008/06/13)
The invention provides anti-apoptotic compositions lysophosphatidic acids and methods for making and using the compositions. Such compositions can also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene glycols. The compositions can additionally contain other pharmaceutically effective agents such as drugs, antibiotics, wound healing agents and antioxidants.
PROCESS FOR REGIOSELECTIVE PREPARATION OF GLYCEROL, DERIVATIVE AND INTERMEDIATE THEREFOR
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Page/Page column 15, (2008/06/13)
Disclosed is a process for regioselective preparation of l-palmitoyl-2-linoleoyl-3-acetylglycerol which is known as having activities for proliferation of hematopoietic stem cells and megakaryocytes, and an intermediate for the same. The process for preparation of l-palmitoyl-2-linoleoyl-3-acetylglycerol includes the steps of obtaining (2-alkoxy-2-methyl-[l,3]-dioxolane-4-yl)methanol by reacting glycerol and trialkylorthoacetate; obtaining 1-acetyl glycerol by hydrolyzing (2-alkoxy-2-methyl-[l,3]-dioxolane-4-yl)methanol; obtaining l-palmitoyl-3-acetyl glycerol by reacting 1-acetyl glycerol and palmitic acid derivative; and reacting l-palmitoyl-3-acetyl glycerol and linoleic acid derivative. l-palmitoyl-2-linoleoyl-3-acetylglycerol can also be prepared by the steps of obtaining l-palmitoyl-3-acetyl glycerol by hydrolyzing palmitic acid (2-alkoxy-2-methyl-[l,3] dioxolane- 4-yl)methyl ester; and reacting l-palmitoyl-3-acetyl glycerol and linoleic acid derivative.
Optically active oxiranes. Synthesis of PAF (Platelet Aggregating Factor)
Cimetiere, B,Jacob, L,Julia, M
, p. 926 - 938 (2007/10/02)
A number of epoxides bearing no function in the α-position have been converted into β-hydroxy sulfonium salts.Association with an otically active acid (dibenzoyltartaric) allowed the resolution.This method has been used to prepare the optically active glycidol octadecyl ether which was converted into (-) PAF. Key words: oxiranes / resolution / PAF synthesis
