7501-64-6Relevant academic research and scientific papers
A Direct Approach to Enantiopure Propionate Derivatives from Ethyl Lactate
Clemente-Tejeda, David,Lara, Juan Carlos Ortiz,Zard, Samir Z.
, p. 3393 - 3399 (2016/09/12)
The S-propargyl xanthate derived from ethyl (S)-lactate reacts upon heating with various acidic substances to give the propionate transfer product in high yield and with complete inversion of configuration.
Synthesis and properties of N-substituted saccharin derivatives
Soubh,Besch,Otto, Hans-Hartwig
, p. 384 - 392 (2007/10/03)
Four different routes for the synthesis of saccharin containing peptids were studied. While reactions between saccharin sodium and α-halogeno acids were limited to two examples, reactions of sulfobenzoic anhydride (4) or saccharin-N-carboxylate (6) with amino acid esters yielded the ring opened products 5 and 7. Finally, we found, that the reaction between the benzoxathiol derivative 8 and amino acid derivatives represents a versatile route to the peptidic compounds 9 and 11. Hydrolysis and hydrogenolysis were studied, and by combination of the different routes the "saccharin tripeptides" 18 were obtained. Structures and stereochemistry were elucidated by spectroscopic and chromatographic methods. Selected compounds were tested as sweeteners of as inhibitors of elastase, but no exiting results were found.
