7501-94-2

Usage

Type of alcohol

Secondary alcohol

Hydroxyl group attachment

To a carbon atom bonded to two other carbon atoms

Chemical structure

Butane backbone with a hydroxyl group on the second carbon atom, and two phenyl groups on the first and third carbon atoms

Applications

a. Organic synthesis as a chiral auxiliary
b. Building block for pharmaceuticals and fine chemicals
c. Fragrance ingredient in perfumes
d. Flavoring agent in food products

Pharmacological activities

a. Anti-inflammatory properties
b. Analgesic properties

Upstream product

• 60-29-7 diethyl ether 
• 16282-16-9 1,2-diphenyl-butan-1-one 
• 677-22-5 tert-butylmagnesium chloride 
• 925-90-6 ethylmagnesium bromide 
• 1439-07-2 trans-Stilbene oxide 
• 1689-71-0 cis-1,2-diphenyloxirane 
• 645-49-8 cis-stilben 
• 97-93-8 triethylaluminum 
• 451-40-1 phenyl benzyl ketone 

Relevant academic research and scientific papers

Diastereoselective friedel-crafts alkylation of indoles with chiral α-phenyl benzylic cations. Asymmetric synthesis of anti-1,1,2- triarylalkanes

(Chemical Equation Presented) The reactions of chiral benzyl carbocations bearing α-phenyl substituents with N-sulfonylated indoles afford 1,1,2-triarylalkanes with antiselectivities. This outcome is a reversal of facial diastereoselectivity relative to B

Lewis base-catalyzed addition of trialkylaluminum compounds to epoxides

A novel concept for catalytic epoxide alkylation has been developed. Lewis bases like phosphanes, arsanes, stibanes, and sulfides were found to catalyze the alkylation of symmetrical epoxides with trialkylaluminum compounds very effectively at a 5 mol % level. Cyclic as well as acyclic epoxides were readily alkylated in good yields. In reactions with terminal epoxides a significant enhancement of rate and/or regioselectivity was noted in the Lewis base-catalyzed process. Coordination of the Lewis base to the Lewis acidic aluminum reagent was proved by 27Al and 31p NMR spectroscopy and is proposed to form a more nucleophilic alkylating agent.