75018-08-5Relevant academic research and scientific papers
Studies on Pyrazines. 24. A Simple and Versatile Synthetic Method for 3-Alkoxy- and 3-Aminopyrazinecarbonitriles
Sato, Nobuhiro,Matsui, Nobuo
, p. 1689 - 1692 (2007/10/02)
New and concise synthetic methods of 3-alkoxy- and 3-aminopyrazinecarbonitriles by nucleophilic displacement of 3-phenylsulfonylpyrazinecarbonitriles are reported.
Condensation Reactions of (1E,3E)-4-Amino-3-cyano-4-methoxy-1-phenyl-2-azabutadiene and Electrocyclizations of Diazatrienes
Freeman, Fillmore,Kim, Darrick S. H. L.
, p. 550 - 552 (2007/10/02)
(1E,3E)-4-Amino-3-cyano-4-methoxy-1-phenyl-2-azabutadiene (2) reacts with 2-methoxypropene in refluxing methylbenzene in the presence of catalytic pyridinium p-toluenesulfonate (PPTS) to give 2-cyano-5,5-dimethyl-3-methoxy-6-phenyl-4,5-dihydro-1,4-diazabe
One-step Preparation of 3-Alkoxypyrazine-2-carbonitriles from Pyrazine-2,3-dicarbonitriles and Related Reactions
Kojima, Takakazu,Nagasaki, Fumihiko,Ohtsuka, Yozo
, p. 455 - 459 (2007/10/02)
A series of 5,6-disubstituted 3-alkoxypyrazine-2-carbonitriles (2a-i) were prepared from 5,6-disubstituted pyrazine-2,3-dicarbonitriles (1a-d) by direct substitution with alcohols.Treatment of 1 with amines gave either pyrrolopyrazines (3a,b) or substitution products (4,5).In a low temperature range, 1 afforded imidates and related compounds (6-11).The preference among these reactions depended on the 5,6-substituents and on the reaction conditions.
