75018-16-5Relevant academic research and scientific papers
One-step Preparation of 3-Alkoxypyrazine-2-carbonitriles from Pyrazine-2,3-dicarbonitriles and Related Reactions
Kojima, Takakazu,Nagasaki, Fumihiko,Ohtsuka, Yozo
, p. 455 - 459 (2007/10/02)
A series of 5,6-disubstituted 3-alkoxypyrazine-2-carbonitriles (2a-i) were prepared from 5,6-disubstituted pyrazine-2,3-dicarbonitriles (1a-d) by direct substitution with alcohols.Treatment of 1 with amines gave either pyrrolopyrazines (3a,b) or substitution products (4,5).In a low temperature range, 1 afforded imidates and related compounds (6-11).The preference among these reactions depended on the 5,6-substituents and on the reaction conditions.
