75031-66-2Relevant articles and documents
Rapid assessment of protecting-group stability by using a robustness screen
Collins, Karl D.,Ruehling, Andreas,Lied, Fabian,Glorius, Frank
supporting information, p. 3800 - 3805 (2014/04/03)
An experimentally simple method has been developed to rapidly establish the stability of widely utilized silyl, acetal, and carbamate protecting groups to a given set of reaction conditions. Assessment of up to twelve protecting groups in a single experiment has been demonstrated. Evaluation of this protocol in two unrelated synthetic transformations suggests that this method can be used to select appropriate protecting groups in the design of synthetic routes.
CHEMOSELEKTIVE MONO- UND DISILYLETHERBILDUNG AUS TERTIAEREN UND SEKUNDAEREN SILANEN
Horner, Leopold,Mathias, Johann
, p. 155 - 174 (2007/10/02)
Tertiary and secondary silanes are O-selective.With alcohols the corresponding silyl ethers are formed.Cesium fluoride/imidazole)CsF/Im) is a better activating system than CsF alone.Primary OH groups are silylated remarkably faster under CsF/Im activation
