7505-15-9

Basic information

• Product Name: 2-(diphenylmethyl)-1,3,5-trimethylbenzene
• CAS NO: 7505-15-9
• Molecular Formula: C₂₂H₂₂
• Molecular Weight: 286.4101
• Mol File: 7505-15-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 404°C at 760 mmHg
• Flash Point: 194.6°C
• Density: 1.017g/cm³
• Vapor Pressure: 2.28E-06mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 2-(diphenylmethyl)-1,3,5-trimethylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(diphenylmethyl)-1,3,5-trimethylbenzene(7505-15-9)
• EPA Substance Registry System: 2-(diphenylmethyl)-1,3,5-trimethylbenzene(7505-15-9)

Safety Data

• Hazardous Substances Data: 7505-15-9(Hazardous Substances Data)

Usage

General Description

2-(diphenylmethyl)-1,3,5-trimethylbenzene is a chemical compound that belongs to the class of hydrocarbons. It is a type of aromatic hydrocarbon, meaning it contains a ring of carbon atoms with alternating single and double bonds. The chemical is characterized by its three methyl groups and a diphenylmethyl group attached to the benzene ring. It is commonly used as a building block in the synthesis of various organic compounds and can be found in some industrial processes. The chemical's structure and properties make it a versatile intermediate for the production of a wide range of products, including pharmaceuticals, fragrances, and plastics.

Upstream product

• 91-01-0 1,1-Diphenylmethanol 
• 108-67-8 1,3,5-trimethyl-benzene 
• 119-61-9 benzophenone 
• 5980-97-2 mesitylboronic acid 
• 19672-37-8 3-benzhydryl-pentane-2,4-dione 
• 776-74-9 Bromodiphenylmethane 
• 42100-74-3 ((octyloxy)methylene)dibenzene 
• 954-67-6 benzhydryl acetate 

Relevant articles and documents

Cascade Reductive Friedel-Crafts Alkylation Catalyzed by Robust Iridium(III) Hydride Complexes Containing a Protic Triazolylidene Ligand

The synthesis of complex molecules like active pharmaceutical ingredients typically requires multiple single-step reactions, in series or in a modular fashion, with laborious purification and potentially unstable intermediates. Cascade processes offer attractive synthetic remediation as they reduce time, energy, and waste associated with multistep syntheses. For example, triarylmethanes are traditionally prepared via several synthetic steps, and only a handful of cascade routes are known with limitations due to high catalyst loadings. Here, we present an expedient catalytic cascade process to produce triarylmethanes. For this purpose, we have developed a bifunctional iridium system as the efficient catalyst to build heterotriaryl synthons via reductive Friedel-Crafts alkylation from ketones, arenes, and hydrogen. The catalytically active species were generated in situ from a robust triazolyl iridium(III) hydride complex and acid and is composed of a metal-bound hydride and a proximal ligand-bound proton for reversible dihydrogen release. These complexes catalyze the direct hydrogenation of ketones at slow rates followed by dehydration. Appropriate adjustment of the conditions successfully intercepts this dehydration and leads instead to efficient C-C coupling and Friedel-Crafts alkylation. The scope of this cascade process includes a variety of carbonyl substrates such as aldehydes, (alkyl)(aryl)ketones, and diaryl ketones as precursor electrophiles with arenes and heteroarenes for Friedel-Crafts coupling. The reported method has been validated in a swift one-step synthesis of the core structure of a potent antibacterial agent. Excellent yields and exquisite selectivities were achieved for this cascade process with unprecedentedly low iridium loadings (0.02 mol %). Moreover, the catalytic activity of the protic system is significantly higher than that of an N-methylated analogue, confirming the benefit of the Ir-H/N-H hydride-proton system for high catalytic performance.

Metal-Free C-O Bond Functionalization: Catalytic Intramolecular and Intermolecular Benzylation of Arenes

A catalytic, metal-free intramolecular rearrangement of benzyl phenyl ethers using nitrosonium salt as a catalyst is described. The optimized reaction conditions enabled a catalytic and metal-free Friedel-Crafts alkylation reaction with benzylic alcohols, producing water as the stoichiometric byproduct. A comprehensive scope (>50 examples) for both approaches and application in drug synthesis were demonstrated. Mechanistic studies suggest a Lewis acid-based mechanism for the metal-free Friedel-Crafts reaction.

SO3H-functionalized organic-inorganic ionic liquids based on polyoxometalates characterization and their application in C-C coupling reaction

Different ionic liquids (ILs) with SO3H as functional group were achieved by combining SO3H-functionalized organic cations and polyoxometalates (POM). The obtained salts were characterized and their catalytic activities investigated