7505-91-1

Usage

Uses

Used in Organic Synthesis and Medicinal Chemistry:
(2E)-1,4-diphenylbut-2-ene-1,4-diol is used as a building block for the synthesis of various pharmaceuticals and biologically active compounds, particularly those targeting estrogen receptors.
Used in Antioxidant and Anti-inflammatory Research:
(2E)-1,4-diphenylbut-2-ene-1,4-diol is being studied for its potential antioxidant and anti-inflammatory properties, which could contribute to the development of new treatments for various diseases and conditions.
Used in the Development of Fluorescent Materials:
(2E)-1,4-diphenylbut-2-ene-1,4-diol has applications in the development of fluorescent materials for electronic devices and sensors, due to its unique chemical structure and properties.

Upstream product

• 4393-06-0 1-Phenyl-2-propen-1-ol 
• 100-52-7 benzaldehyde 
• 4482-17-1 rac-1,4-diphenylbut-2-yne-1,4-diol 
• 959-28-4 1,4-diphenylbut-2-ene-1,4-dione 

Relevant academic research and scientific papers

Synthesis of Aromatic Retinoids and Curcuminoids and Evaluation of their Antiproliferative, Antiradical, and Anti-inflammatory Activities

Natural retinoids and curcuminoids are known for their broad spectrum of biological properties, such as antioxidant, anti-inflammatory, antitumor, and so forth. In this work, a convenient synthesis of aromatic retinoids and curcuminoids from vinyl or allyl ketones, and the corresponding alcohols, using olefin metathesis as a key reaction, was elaborated. The best yields and diastereoselectivities were obtained from allylic or homoallylic alcohols by employing the two-step cross-metathesis/oxidation procedure. The synthesized analogues were tested for their antiproliferative activity on human cancer cell lines of various origin (leukemia CEM, adenocarcinoma MCF7, cervical carcinoma HeLa) as well as for their antioxidant and anti-inflammatory activity in vitro. All examined derivatives exhibited strong anti-inflammatory activity in vitro without affecting cell viability. They also showed strong cytotoxicity against leukemia cell line CEM, except for 18 and 35. The antioxidant activity of the tested compounds was rather weak.

Nucleophilic Attack on a Carbonyl Group Conjugated to a Chiral Centre: A Search For a Vinylogous Cram's Rule

In a search for a vinylogous version of Cram's rule, 1,4-diphenylbut-2-ene-1,4-dione (5), 4-methoxy-1,4-diphenylbut-2-en-1-one (9), and hex-3-ene-2,5-dione (13) are found to be reduced with low or negligible diastereoselectivity.Similarly, the phenyl Grignard reagent showed no diastereoselectivity in its reaction with 4-methoxy-4-phenylbut-2-enal (12)