75057-28-2Relevant articles and documents
Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors
Kulikov, Alexander S.,Epishina, Margarita A.,Zhilin, Egor S.,Shuvaev, Alexander D.,Fershtat, Leonid L.,Makhova, Nina N.
, p. 42 - 45 (2021)
A simple and effective protocol for the synthesis of 2H-pyrazolo[3,4-d]pyridazine 5,6-dioxides includes a transformation of accessible 3,4-diacetyl-5-methyl-1H-pyrazoles into the corresponding 1,4-dioximes followed by their N2O4- mediated oxidative cyclization. All transformations proceed under mild conditions in good to high yields. According to the Griess assay, synthesized 2H-pyrazolo[3,4-d]pyridazine 5,6-dioxides showed promising NO-donor profiles producing NO in a wide range of concentrations.
Studies on Nitrile Imines : Synthesis of Pyrazoles Using Active Methylene Compounds
Tewari, R. S.,Parihar, P.
, p. 217 - 218 (2007/10/02)
A series of C-ethoxycarbonyl and C-acetyl derivatives of hydrazidoyl halides have been prepared and reacted with carbanions of active methylene compounds to afford substituted pyrazoles (II and III) in good yields.The formation of pyrazoles involves the alkylation of active methylene group by hydrazidoyl halides to give the acyclic hydrazones, which then undergo cyclization to give the corresponding pyrazoles.The structural assignments of the products are based on spectral and chemical evidences.
