75057-29-3

Upstream product

• 20147-56-2 bromo-(4-nitro-phenylhydrazono)-acetic acid ethyl ester 
• 123-54-6 acetylacetone 
• 623-73-4 diazoacetic acid ethyl ester 
• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 20147-56-2 C₁₀H₁₀N₂O₂BrNO₂ 

Downstream Products

• 132330-72-4 4-[3,4-Dimethyl-2-(4-nitro-phenyl)-7-oxo-2,7-dihydro-pyrazolo[3,4-d]pyridazin-6-yl]-benzoic acid 
• 132330-66-6 3,4-Dimethyl-2-(4-nitro-phenyl)-6-phenyl-2,6-dihydro-pyrazolo[3,4-d]pyridazin-7-one 
• 132330-69-9 3,4-Dimethyl-2,6-bis-(4-nitro-phenyl)-2,6-dihydro-pyrazolo[3,4-d]pyridazin-7-one 
• 5078-55-7 1-[5-methyl-1-(4-nitrophenyl)-1H-pyrazol-4-yl]ethanone 
• 132330-60-0 7-Chloro-3,4-dimethyl-2-(4-nitro-phenyl)-2H-pyrazolo[3,4-d]pyridazine 
• 854699-78-8 4-acetyl-5-methyl-1-(4-nitro-phenyl)-1H-pyrazole-3-carboxylic acid 

Relevant academic research and scientific papers

In Situ Generation of Nitrilimines from Aryldiazonium Salts and Diazo Esters: Synthesis of Fully Substituted Pyrazoles under Room Temperature

A novel one-pot synthesis for fully substituted pyrazoles has been well developed via the in situ generation of nitrilimines from aryldiazonium salts and diazo esters and a subsequent cycloaddition with 1,3-dicarbonyl compounds. High yields, mild conditio

1,3-Dipolar Cycloaddition of Four Hydrazonoyl Chlorides to β-Diketones and α,β-Unsaturated Ketones

The 1,3-dipolar cycloaddition of four hydrazonoyl chloride derivatives with the sodium salt of unsymmetrical β-diketones (benzoylacetone) offers a versatile method for the regioselective synthesis of 2H-pyrazoles in a similar fashion to the cycloaddition of the nitrilimides with α,β-unsaturated ketones and esters. The structures of the prepared isomeric pyrazole and pyrazoline derivatives were established by spectroscopic and chemical methods.

Studies on Nitrile Imines : Synthesis of Pyrazoles Using Active Methylene Compounds

A series of C-ethoxycarbonyl and C-acetyl derivatives of hydrazidoyl halides have been prepared and reacted with carbanions of active methylene compounds to afford substituted pyrazoles (II and III) in good yields.The formation of pyrazoles involves the alkylation of active methylene group by hydrazidoyl halides to give the acyclic hydrazones, which then undergo cyclization to give the corresponding pyrazoles.The structural assignments of the products are based on spectral and chemical evidences.