5078-55-7

Basic information

• Product Name: 1-[5-methyl-1-(4-nitrophenyl)-1H-pyrazol-4-yl]ethanone
• Synonyms: 1-[5-methyl-1-(4-nitrophenyl)-1H-pyrazol-4-yl]ethanone
• CAS NO: 5078-55-7
• Molecular Weight: 245.238
• Mol File: 5078-55-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-[5-methyl-1-(4-nitrophenyl)-1H-pyrazol-4-yl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[5-methyl-1-(4-nitrophenyl)-1H-pyrazol-4-yl]ethanone(5078-55-7)
• EPA Substance Registry System: 1-[5-methyl-1-(4-nitrophenyl)-1H-pyrazol-4-yl]ethanone(5078-55-7)

Safety Data

• Hazardous Substances Data: 5078-55-7(Hazardous Substances Data)

Usage

Family

Pyrazole family of organic compounds

Building block

Used in the synthesis of more complex organic molecules

Structure

Contains a pyrazole ring, a methyl group at position 5, a nitrophenyl group at position 1, and an ethanone group

Applications

Pharmaceutical research and drug development

Potential

Bioactivity and ability to modulate biological systems

Studies

Investigated for potential pharmacological properties

Fields of application

Medicine and biotechnology

Upstream product

• 260973-82-8 5-methyl-1-(4-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 134653-70-6 ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate 
• 6226-25-1 2,2,2-trifluoroethyl trifluoromethanesulphonate 
• 1404530-79-5 ethyl 3-[5-methyl-1-(4-nitrophenyl)-1H-pyrazol-4-yl]-3-oxopropanoate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 100-16-3 4-nitrophenylhydrazone 
• 123-54-6 acetylacetone 
• 20147-56-2 bromo-(4-nitro-phenylhydrazono)-acetic acid ethyl ester 
• 75057-29-3 ethyl 4-acetyl-5-methyl-1-(4-nitrophenyl)-1H-pyrazole-3-carboxylate 
• 87150-12-7 ethyl 4-acetyl-3-methyl-1H-pyrazole-1-carboxylate 
• 33884-41-2 ethoxylideneacetylacetone 
• 105224-04-2 1-(3-methyl-1H-pyrazol-4-yl)ethanone 
• 350-46-9 4-Fluoronitrobenzene 
• 854699-78-8 4-acetyl-5-methyl-1-(4-nitro-phenyl)-1H-pyrazole-3-carboxylic acid 

Downstream Products

• 1404532-84-8 {3-[4-(4-acetyl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-chloro-indol-1-yl}acetic acid 
• 1404532-60-0 {3-[4-(4-acetyl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-chloro-indol-1-yl}acetic acid methyl ester 
• 1404530-92-2 1-[1-(4-aminophenyl)-5-methyl-1H-pyrazol-4-yl]ethanone 

Relevant articles and documents

N -[6-(4-Butanoyl-5-methyl-1 H -pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1 H -indole-3-carboxamide (SAR216471), a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist

In the search of a potential backup for clopidogrel, we have initiated a HTS campaign designed to identify novel reversible P2Y12 antagonists. Starting from a hit with low micromolar binding activity, we report here the main steps of the optimization process leading to the identification of the preclinical candidate SAR216471. It is a potent, highly selective, and reversible P2Y12 receptor antagonist and by far the most potent inhibitor of ADP-induced platelet aggregation among the P2Y12 antagonists described in the literature. SAR216471 displays potent in vivo antiplatelet and antithrombotic activities and has the potential to differentiate from other antiplatelet agents.

Synthesis and Structures of Pyrazoles from Ethoxymethylene Derivatives of 1,3-Dicarbonyl Compounds and Hydrazines

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